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Master's Dissertation
DOI
10.11606/D.10.2007.tde-16102007-103227
Document
Author
Full name
André Gatti
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Bombonato, Pedro Primo (President)
Ambrosio, Carlos Eduardo
Marques, Fabio Luiz Navarro
Title in Portuguese
Estudo da função glomerular em Golden Retrievers normais, portadores e afetados pela distrofia muscular progressiva (GRMD)
Keywords in Portuguese
Clearance
Creatinina
Distrofia muscular
EDTA-cromo
Medicina nuclear
Abstract in Portuguese
As distrofias musculares em crianças e adolescentes acometem 1 em cada 3000 nascimentos. A distrofia de Duchenne é de origem genética e herança recessiva ligada ao cromossomo X, sendo determinada pela ausência da proteína distrofina, apresenta caráter invariavelmente progressivo, natureza mórbida e fim letal. Até o momento não se conhece tratamento efetivo, mesmo com todo o conhecimento que se tem da etiopatogenia. O objetivo deste estudo foi avaliar, no modelo animal, utilizando cães golden retrievers normais portadores e afetados pela distrofia muscular progressiva, a existência de alterações na função glomerular, através da comparação entre os clearances de creatinina, clearance do radionuclídeo EDTA-cromo e da concentração sérica de uréia e creatinina. Os animais foram divididos em 3 grupos de 9 animais sendo grupo 1 controle, grupo 2 portador e grupo 3 afetados. Todos os animais foram submetidos ao mesmos protocolos de exames. Não foram identificadas alterações significativas entre os grupos ou individualmente, sendo que todos os resultados encontraram-se dentro dos limites de normalidade. Sendo assim lesões renais primárias, obscuras aos testes convencionais, descartando-se uma correlação entre a distrofia muscular e lesão na musculatura dos vasos renais que pudessem levar a alterações da função do órgão.
Title in English
Study of glomerular function in golden retrievers normals, carriers and affected by progressive muscular dystrophy (GRMD)
Keywords in English
Clearance
Creatinine
EDTA-crome
Muscular dystrophy
Nuclear Medicine
Abstract in English
The muscular dystrophys in children and teenagers is taken in 1 each 3000 births. The Duchenne`s dystrophy is from genetics origin and recessive heritage linked to X cromossome, and also determined by the lacre of dystrophyne protein; it shows progressive characteristics, morbid nature and a letal end. So far there is no known effective treatment, even with all the ethiopatogein knowledge. The goal of use of normal golden retrievers dogs, bling then carriers and affected by the progressive muscular dystrophy, the changing existence in the glomerular function through the comparison between the creatinine clearance, EDTA-crome clearance and seric urea and creatinine. Aiming the early diagnostic of the renal pathology. The animals were divided in 3 groups of 9 animals, bling group 1 control animals, group 2 carriers animals and group 3 affected animals. All of then were submitted to the some examinations protocols Their was no relevant identification between the groups or either individually, as all the results were within the expected and natural limits. Likewise, renal primary wounds are not clear in traditional tests made in dystrophyc animals, mainly caused by the muscular wounds in reanal vases harming this way the organ function.
 
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ANDRE_GATTI.pdf (2.51 Mbytes)
Publishing Date
2007-12-06
 
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