• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Master's Dissertation
DOI
10.11606/D.9.2007.tde-07122007-101051
Document
Author
Full name
Fabricio Soares Arantes
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Albuquerque, Cristina Northfleet de (President)
Polakiewicz, Bronislaw
Valduga, Claudete Justina
Title in Portuguese
Comparação das duas principais rotas de obtenção do megazol
Keywords in Portuguese
Antichagásicos
Antiparasitários
Comparação de rotas
Composto heterocíclico
Fármacos sintéticos
Megazol
Planejamento de fármacos
Síntese de fármacos
Toxicidade de reagentes
Abstract in Portuguese
Este trabalho tem como meta o estudo comparativo de duas rotas de síntese do megazol, tomando como base estudos feitos na Faculdade de Ciências Farmacêuticas da USP. Nestes foram observados que a obtenção do megazol pode ser feita por diferentes caminhos sintéticos, modificando processos e reagentes envolvidos na química de heterocíclicos, em particular os imidazóis. Foram avaliadas condições experimentais, rendimentos parciais e globais bem como as características de reagentes envolvidos nos processos indicados.
Title in English
Comparative study between two main obtaining routes of the Megazol
Keywords in English
Drug synthesis
Megazol
Routes comparison
Toxicity of reagents
Abstract in English
The scope of the present work is the analogy study over the two main routes on megazol synthesis, based on studies previously accomplished at the College of Pharmaceutical Sciences of USP. In the results of the above referred studies, it was observed that the obtaining of the megazol can be achieved by different synthetic ways, by modifying processes and reagents related to the chemical properties of heterocyclic compounds, particularly with the imidazoles. Experimental conditions, both partial and final yields as well as the characteristics of the reagents evolved in the indicated processes were evaluated.
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
Fabricio.pdf (390.34 Kbytes)
Publishing Date
2007-12-11
 
WARNING: Learn what derived works are clicking here.
All rights of the thesis/dissertation are from the authors
Centro de Informática de São Carlos
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2019. All rights reserved.