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Master's Dissertation
DOI
10.11606/D.9.2004.tde-01042015-105316
Document
Author
Full name
Cecilia Rodrigues de Silva Amaro
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2004
Supervisor
Committee
Albuquerque, Cristina Northfleet de (President)
Chin, Chung Man
Fischer, Dominique Corinne Hermine
Title in Portuguese
Proposição de nova rota de síntese do megazol
Keywords in Portuguese
Antiparasitários (Desenvolvimento)
Fármacos sintéticos (Desenvolvimento)
Planejamento de fármacos
Tecnologia farmacêutica
Abstract in Portuguese
Em 1968, um composto do tipo 5-nitroimidazol, o megazol, foi sintetizado por Berkelhammer e Asato e demonstrou largo espectro de ação biológica. Em 1980, pesquisadores brasileiros determinaram excelente atividade desta molécula contra o Tripanosoma cruzi, em ratos, por via oral. Constam da literatura quatro rotas para a obtenção deste fármaco, que podem ser otimizadas no tocante ao aumento da produtividade e minimização dos riscos. A nova rota, ora proposta, é uma alternativa para a síntese do megazol, realizada somente em três etapas de fácil execução, abrindo caminho para obtenção de seus análogos estruturais.
Title in English
Proposition new synthesis route of megazol
Keywords in English
Antiparasitic (Development)
Drugs Planning
Pharmaceutical technology
Synthetic drugs (Development)
Abstract in English
In 1968, Berkelhammer and Asato synthesized a compound of the 5-nitroimidazole group, called megazol. This compound demonstrated a high biological activity. In 1980, brazilian researchers tested the megazol in mices and they discovered an excellent activity of this against Chagas' disease. There are four routes to synthesize these compound indicated in the literature. Actually, these routes can be optimized to achieve the yield and minimization of the risks involved in the unitary processo The new route proposed is an alternative to obtain the megazol in only three stages of easy perform. This method makes way to structural analogues of this drug.
 
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CeciliaRSAmaro_M.pdf (2.21 Mbytes)
Publishing Date
2015-04-01
 
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