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The biological value of the proteins of Saccharomyces cerevisiae grown in sugar cane molasses was studied in rats during 3 generations. The animals were fed two levels of yeast protein either 10% or 25% and compared with casein fed controls. In the first generation the PER and body weight were significantly lower for the animals receiving the yeast in their diet. In the 2^rd and 3^rd generation the growth was retarded even more in relation to what had been observed for the first one, specially at 10% protein level. A decreased male fertility was also observed at litter born from rats fed either 10% or 25% protein. The digestibility for casein was 90% and 80% for single cell protein.