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Doctoral Thesis
DOI
https://doi.org/10.11606/T.87.2010.tde-03032011-091820
Document
Author
Full name
Paulo Cesar Costa dos Santos
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Lopez, Luis Fernandez (President)
Abe, Jair Minoro
Couto Junior, Euro de Barros
Machado, Joaquim Aparecido
Vicente, Elisabete Jose
Title in Portuguese
Banco de dados inteligente e ferramentas associadas de sequências, mutações e resistências ao antiretrovirais do vírus HIV.
Keywords in Portuguese
Antivirais
Mutagênese
Redes neurais
Retroviridae
Síndrome de imunodeficiência adquirida
Abstract in Portuguese
Os bancos de dados atualizados constituídos a partir de informações dos prontuários de pacientes HIV+ são importantes fontes para a realização de pesquisas clínicas e epidemiológicas de forma rápida e eficiente. A elevada variabilidade do HIV-1, resultado, entre outros fatores, da ausência de mecanismos eficientes de reparo durante os estágios da replicação viral, contribui para a emergência de cepas resistentes aos antiretrovirais. O objetivo deste trabalho é desenvolver e implementar um banco dados inteligente utilizando a Rede Neural Artificial Paraconsistente (RNAP), assentada na Lógica Paraconsistente Anotada, para auxiliar o mapeamento de informações contidas nos diversos formulários a fim de apoiar o mapeamento das informações provenientes dos diferentes registros médicos produzidos. O banco de dados será usado principalmente para apoiar o processo de decisão sobre a prescrição da terapia antiretroviral. Os resultados obtidos durante a pesquisa mostram que a técnica pode se tornar uma ferramenta promissora.
Title in English
Intelligent database tools and associated sequences, mutations and resistance to antiretrovirals in HIV virus.
Keywords in English
Acquired immunodeficiency syndrome
Antiviral
Mutagenesis
Neural networks
Retroviridae
Abstract in English
Updated databases made from information collected from HIV+ patients are important references to quickly and efficiently design clinical and epidemiologic studies. The high levels of variability of the HIV-1 virus, among other factors, the result of the absence of repair mechanisms during replication, strongly contribute to the establishment of resistance to antiretroviral therapy. The main objective of this study is the design and implementation of an inteligent database using the concept of Paraconsistent Artificial Neural Network (PANN) based on the Paraconsistent Annotated Logic, in order to support the mapping of the information coming from the different medical records produced. The database will be used primarily to support the decision process on the antiretroviral therapy prescription. Results obtained during the research show that the technique may become a promising tool.
 
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Publishing Date
2011-08-11
 
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