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Master's Dissertation
DOI
https://doi.org/10.11606/D.85.2009.tde-29032012-144938
Document
Author
Full name
Thyago Fressatti Mangueira
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2009
Supervisor
Committee
Rodrigues, Letícia Lucente Campos (President)
Furquim, Tânia Aparecida Correia
Rocha, Felícia Del Gallo
Title in Portuguese
Avaliação dosimétrica da solução fricke gel usando a técnica de espectrofotometria para aplicação na dosimetria de elétrons e nêutrons
Keywords in Portuguese
dosimetria de elétrons
dosimetria de nêutrons
dosímetros químicos
Abstract in Portuguese
Neste trabalho as principais características dosímetricas da solução Fricke Xilenol Gel (FXG) foram estabelecidas para futura aplicação clínica na dosimetria de elétrons. As curvas de dose resposta para feixes de nêutrons térmicos para pesquisa em Terapia por Captura de Nêutrons (BNCT) e feixes elétrons de aplicação industrial também foram determinadas. A técnica padrão de leitura utilizada foi espectrofotometria. Para o feixe clínico as reprodutibilidades intra e inter-lotes da solução FXG são melhores que 1,4 % e 5,1 % respectivamente, o comportamento da resposta para o intervalo de dose entre 0,2 e 40 Gy é linear e independente da energia e da taxa de dose para o intervalo estudado. Devido aos efeitos da oxidação natural do FXG o tempo ótimo entre o preparo e a irradiação é de 24h e o comportamento da curva de dose resposta não se altera no período estudado para a variação da absorvância líquida do dosímetro. Para o estudo com o campo de nêutrons as curvas de dose resposta do FXG apresentaram comportamento linear em todo intervalo de dose estudado, e para campos industriais de elétrons o comportamento é exponencial decrescente. De acordo com os resultados obtidos para os feixes de radiação estudados, não houve alteração na posição das bandas características do espectro de absorção do FXG. Como testes adicionais, foi determinada a viabilidade do uso do método de leitura do FXG por imagens fotográficas digitais e aplicação do FXG na dosimetria para braquiterapia intracavitária. O bom desempenho do dosímetro FXG nos testes realizados indica que este pode ser utilizado na avaliação tridimensional da dose em tratamento radioterápicos.
Title in English
Dosimetric evaluation of the fricke gel dosimeter using the spectrophotometric technique for application in electron and neutron dosimetry
Keywords in English
boron
chemical dosemeters
electron dosimetry
neutron capture therapy
neutron dosimetry
radiation doses
spectrophotometry
Abstract in English
In this work the main dosimetric characteristics of the Fricke Xylenol Gel (FXG) solution were established for further application in the measurement of dose distribution of clinical electron fields. The dose-response curves of the FXG in a neutron field were also evaluated for the research in Boron Neutron Capture Therapy (BNCT) and industrial electron fields. The standard reading technique was the spectrophotometric. For the clinical field, the intra and inter-batch reproducibility are better than 1.4% and 5.1 %, respectively, the response presents a linear behavior for doses ranging from 0.2 to 40 Gy independently of the energy and the dose rate in the studied ranges. Due to the effects of the FXG natural oxidation, the optimum elapsed time between FXG preparation and irradiation was established as 24h period and the behavior of the dose-response curve of the FXG using the variation in the absorbance relative to the non-irradiated dosimeter as a basis during the whole studied period were not altered. The dose-response to the industrial electron beam presented an exponential decreasing behavior and the neutron beam for research in BNCT presented a linear behavior for the complete studied dose range. According to the obtained results for the different types of radiation studied for the FXG, there was no change in the position of the characteristic bands of the absorption spectrum due to the interaction of these radiation types. Additional tests were performed to determine the digital photographic imaging of FXG analyses viability and the application of FXG dosimetry on intracavitary brachytherapy. The good performance of the FXG dosimeter in the tests that were carried out indicates that this dosimeter may be applied to the tri-dimensional dose evaluation in radiotherapic treatments using electrons and neutron beams.
 
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Publishing Date
2012-04-04
 
WARNING: The material described below relates to works resulting from this thesis or dissertation. The contents of these works are the author's responsibility.
  • MANGUEIRA, T.F., et al. Gamma/neutron dose evaluation using Fricke gel and alanine gel dosimeters to be applied in boron neutron capture therapy [doi:10.1016/j.apradiso.2010.01.027]. Applied Radiation and Isotopes [online], 2010, vol. 68, n. -1, p. 791-794.
  • MANGUEIRA, T. F.. Dose rate response analyses of FXG using spectrophotometric technique. In International Congress of the International Radiation Protection Association (IRPA), 12, Buenos Aires, 2008.
  • MANGUEIRA, T.F.. Determinação dos Limites de Detecção em Dosimetria FXG para Elétrons. In , , .
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