Estudo fitoquímico comparativo entre espécies de mikania cordifolia (L. F.) WILLD

Oliveira, Patricia Abrão de

doi:10.11606/T.59.2007.tde-04062009-145515

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Doctoral Thesis

DOI

https://doi.org/10.11606/T.59.2007.tde-04062009-145515

Document

Doctoral Thesis

Author

Oliveira, Patricia Abrão de (Catálogo USP)

Full name

Patricia Abrão de Oliveira

E-mail

Institute/School/College

Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto

Knowledge Area

Chemistry

Date of Defense

2007-03-28

Published

Ribeirão Preto, 2007

Supervisor

Oliveira, Dioneia Camilo Rodrigues de (Catálogo USP)

Committee

Oliveira, Dioneia Camilo Rodrigues de (President)
Bastos, Jairo Kenupp
Cunha, Wilson Roberto
Kato, Massuo Jorge
Silva, Dulce Helena Siqueira

Title in Portuguese

Estudo fitoquímico comparativo entre espécies de mikania cordifolia (L. F.) WILLD

Keywords in Portuguese

Asteraceae
Eupatorieae
Mikania Cordifolia (L. F.) WILLD

Abstract in Portuguese

No presente trabalho, espécimes de Mikania cordifolia coletados em Ribeirão Preto, São Carlos, Campos do Jordão e Monte Verde são analisados comparativamente por métodos cromatográficos (CG e CLAE) para a pesquisa de triterpenóides, lactonas sesquiterpênicas e flavonóides. Todos os espécimes de M. cordifolia analisados apresentaram os triterpenóides -Amirina, -Amirina, Lupeol, Lupenona, Taraxasterol, Pseudotaraxasterol, Acetato de -Amirina, Acetato de -Amirina, Acetato de Lupeol, Acetato de Taraxasterol, Campesterol, Estigmasterol e -Sitosterol, as lactonas sesquiterpênicas 14-hidroxi-15[2-hidroximetilacriloiloxi]-germacra-1(10)E,4Z-11(13)-trien-12,8-olídeo, 14-hidroxi-15[2-hidroxi,2-metilpropanoiloxi]-germacra-1(10)E,4Z-11(13)-trien-12,8-olídeo e 14-hidroxi-15[2,3-epoxi,2-metilpropanoiloxi]-germacra-1(10)E,4Z-11(13)-trien-12,8-olídeo, os flavónóides Quercetina-3-O--galactosídeo e Rhamnazina e o ácido 3,4-diidroxi-benzóico. Apenas os espécimes de Ribeirão Preto e São Carlos apresentaram Friedelina. O extrato aquoso de M. cordifolia foi avaliado para atividade antiofídica, mostrando-se efetivo na diminuição do edema de pata de camundongo induzido por veneno de Bothrops moojeni.

Title in English

Comparative Phytochemistry between specimens of the Mikania cordifolia (L. f.) Willd

Keywords in English

Asteraceae
Mikania
Phytochemical study

Abstract in English

In the present work, specimens of Mikania cordifolia collected at Ribeirão Preto, São Carlos, Campos do Jordão and Monte Verde were analyzed comparatively for triterpenoids, sesquiterpene lactones and flavonoids by chromatographic methods (GC and HPLC). All M. cordifolia specimens analyzed showed the triterpenoids -Amyrin, - Amyrin, Lupeol, Lupenone, Taraxasterol, Pseudotaraxasterol, -Amyrin Acetate, - Amyrin Acetate, Lupeol Acetate, Taraxasterol Acetate, Campesterol, Stigmasterol e -Sitosterol, the sesquiterpene lactones 14-hydroxy-15[2 -hydroxymethylacryloyloxygermacra- 1(10)E,4Z-11(13)-trien-12,8 -olide, 14-hydroxy-15[2 -hydroxy,2 - methylpropanoyloxy]-germacra-1(10)E,4Z-11(13)-trien-12,8 -olide e 14-hydroxy- 15[2 ,3 -epoxy,2 -methylpropanoyloxy]-germacra-1(10)E,4Z-11(13)-trien-12,8 -olide, the flavonoids Quercetin-3-O- -galactoside and Rhamnazyn and the compound 3,4- dihydroxy-benzoic acid. Only specimens collected at Ribeirão Preto and São Carlos showed Friedelin. The aqueous extract of M. cordifolia was evaluated for antiofidic activity and was found effective in reducing mice paw edema induced by venom of Bothrops moojeni

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Publishing Date

2009-07-15

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