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Master's Dissertation
DOI
https://doi.org/10.11606/D.55.2011.tde-09062011-151222
Document
Author
Full name
Alessandra Cristiane Sibim
Institute/School/College
Knowledge Area
Date of Defense
Published
São Carlos, 2011
Supervisor
Committee
Cancho, Vicente Garibay (President)
Bolfarine, Heleno
Louzada Neto, Francisco
Title in Portuguese
Estimação e diagnóstico na distribuição exponencial por partes em análise de sobrevivência com fração de cura
Keywords in Portuguese
Análise de sobrevivência
Divergência de Kullback-Leibler
Inferência bayesiana
Medidas de diagnóstico bayesiano
Métodos MCMC
Abstract in Portuguese
O principal objetivo deste trabalho é desenvolver procedimentos inferências em uma perspectiva bayesiana para modelos de sobrevivência com (ou sem) fração de cura baseada na distribuição exponencial por partes. A metodologia bayesiana é baseada em métodos de Monte Carlo via Cadeias de Markov (MCMC). Para detectar observações influentes nos modelos considerados foi usado o método bayesiano de análise de influência caso a caso (Cho et al., 2009), baseados na divergência de Kullback-Leibler. Além disso, propomos o modelo destrutivo binomial negativo com fração de cura. O modelo proposto é mais geral que os modelos de sobrevivência com fração de cura, já que permitem estimar a probabilidade do número de causas que não foram eliminadas por um tratamento inicial
Title in English
Estimation and diagnostics for the piecewise exponential distribution in survival analysis with fraction cure
Keywords in English
Bayesian inference
Kullback-Leibler divergence
MCMC methods
Measures of diagnostic bayesian
Survival analysis
Abstract in English
The main objective is to develop procedures inferences in a bayesian perspective for survival models with (or without) the cure rate based on piecewise exponential distribution. The methodology is based on bayesian methods for Markov Chain Monte Carlo (MCMC). To detect influential observations in the models considering bayesian case deletion influence diagnostics based on the Kullback-Leibler divergence (Cho et al., 2009). Furthermore, we propose the negative binomial model destructive cure rate. The proposed model is more general than the survival models with cure rate, since the probability to estimate the number of cases which were not eliminated by an initial treatment
 
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alessandra.pdf (827.13 Kbytes)
Publishing Date
2011-06-09
 
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