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Master's Dissertation
DOI
https://doi.org/10.11606/D.5.2016.tde-20062016-113022
Document
Author
Full name
Milene Franco de Souza Nunes
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2016
Supervisor
Committee
Caromano, Fátima Aparecida (President)
Hukuda, Michele Emy
Voos, Mariana Callil
Title in Portuguese
Relação entre força muscular e função motora em pacientes com distrofia muscular de Duchenne: acompanhamento de quatro anos
Keywords in Portuguese
Atividade motora
Destreza motora
Distrofia muscular de Duchenne
Estatísticas não paramétricas
Força muscular
Abstract in Portuguese
OBJETIVO: Investigar a relação entre força muscular e função motora, em pacientes com DMD, em um período de 4 anos consecutivos, a partir de avaliações semestrais. MÉTODO: A força muscular foi medida por meio de testes manuais e o cálculo por grupo muscular seguiu o proposto pelo Medical Research Council (MRC) e a função motora pelo método de Medida da Função Motora (MFM), em 43 pacientes (8-30 anos). Foi realizada uma análise descritiva e o teste de correlação de Spearman. Foram investigadas as relações entre pontuações totais e parciais da MRC e da MFM. RESULTADOS: O estudo evidenciou correlações classificadas de moderada a forte relação entre a força muscular e função motora, principalmente com o escore total da MFM e a dimensão D2 (musculatura axial e função motora proximal). Foi encontrada relação negativa moderada entre idade e essas variáveis. CONCLUSÃO: A perda progressiva da função motora tem relação direta e proporcional com a diminuição da força muscular. Quanto maior a idade do paciente, pior sua função motora e força muscular, fornecendo com essa informação, indicadores adicionais da progressão da doença
Title in English
Relationship between muscle strength and motor function in Duchenne muscular dystrophy: follow-up four years
Keywords in English
Duchenne muscular dystrophy
Motor activity
Motor skills
Muscle strength
Statistic nonparametric
Abstract in English
OBJECTIVE: This study investigated this relationship and examined whether muscle strength and/or motor function would be related to age in DMD. METHODS: Muscle strength was measured by the Medical Research Council scale (MRC) and motor function by the Motor Function Measure (MFM) in 43 patients (8-30 yrs). Spearman tests, descriptive analysis, investigated the relationships between total/ partial scores of MRC and MFM. RESULTS: Total MRC and MFM scores were strongly related to each other and moderately related to age. Many strong relationships between partial MRC and MFM scores were found, mostly between partial MRC scores and MFM dimension 2 (axial and proximal motor function). CONCLUSION: It is possible to predict that the progressive loss of motor function has direct relationship to decreased muscle strength. That the older the patient, the worse their motor function and muscle strength, providing with this information, additional indicators of disease progression
 
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Publishing Date
2016-06-20
 
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