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Master's Dissertation
DOI
https://doi.org/10.11606/D.5.2017.tde-07032017-163001
Document
Author
Full name
Henrique Wendling Sava
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2016
Supervisor
Committee
Dedivitis, Rogério Aparecido (President)
Almeida, Ricardo Camillo de
Guimarães, André Vicente
Title in Portuguese
Avaliação morfológica da invasão da cartilagem tireoide no tumor precoce de andar glótico acometendo a comissura anterior
Keywords in Portuguese
Carcinoma de células escamosas
Cartilagem tireoide
Laringe
Laringectomia
Neoplasias laríngeas
Abstract in Portuguese
Introdução: A comissura anterior constitui-se em área de infiltração do câncer glótico, mesmo em estádio precoce. Objetivo: Avaliar o acometimento por tumor da cartilagem da comissura anterior em espécimes de laringectomia frontolateral. Métodos: Foram incluídos 48 pacientes submetidos à laringectomia frontolateral por carcinoma espinocelular T1b/T2. Aspectos epidemiológicos, clínicos e análise morfológica histopatológica foram avaliados. Resultados: Quarenta e dois pacientes (87,5%) tinham lesões T1b e seis (12,5%), T2. Trinta e quatro casos (70,8%) apresentaram tecido sadio entre o tumor e a cartilagem tireoidea, 10 casos (20,8%) tinham tumor contíguo à cartilagem e, em quatro casos (8,3%), houve invasão da cartilagem. Não houve maior risco de desfecho adverso nos grupos com infiltração ou tumor adjacente à cartilagem. Grau de diferenciação, índice mitótico, irregularidade nuclear, presença de nucléolo e necrose tumoral não tiveram relação com invasão da cartilagem. Conclusão: A infiltração da cartilagem tireoidea ocorreu em 8,3% dos tumores e não mudou o desfecho em pacientes submetidos à laringectomia fronto-lateral. As características morfológicas não apresentaram significado estatístico
Title in English
Morphologic evaluation of invasion of the thyroid cartilage in early glottic tumor spreading to the anterior commissure
Keywords in English
Carcinoma,squamous cell
Laryngeal neoplasms
Laryngectomy
Larynx
Thyroid cartilage
Abstract in English
Introduction: The anterior commissure is an area of glottic cancer infiltration, even in early stages. Objective: To evaluate the involvement of cartilage by the tumor of the anterior commissure in surgical specimens of frontolateral laryngectomy. Methods: 48 patients who had undergone frontolateral laryngectomy for T1b/T2 squamous cell carcinoma were included. Epidemiological and clinical aspects as well as morphological histopathological analysis were evaluated. Results: 42 patients (87,5%) had T1b lesions and 6 (12,5%) had T2. Thirty-four cases (70,8%) showed healthy tissue between the tumor and thyroid cartilage, 10 cases (20,8%) had a tumor contiguous with cartilage; and in 4 cases (8,3%) there was cartilage invasion. There was no major risk of adverse closure in the groups with the infiltration or tumor adjacent to cartilage. Grade of cellular differentiation, mitotic index, nuclear irregularity, the presence of nucleolus and tumoral necrosis were not related to cartilage invasion. Conclusion: the infiltration of thyroid cartilage occurred in 8,3% of tumors and did not change the outcome in patients submitted to partial frontolateral laryngectomy. The morphological characteristics did not show any statistical significance
 
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Publishing Date
2017-03-08
 
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