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Doctoral Thesis
DOI
10.11606/T.5.2004.tde-18102005-165332
Document
Author
Full name
Luciano César Pontes de Azevedo
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2004
Supervisor
Committee
Laurindo, Francisco Rafael Martins (President)
Campa, Ana
Carvalho, Carlos Roberto Ribeiro de
Monteiro, Hugo Pequeno
Souza, Heraldo Possolo de
Title in Portuguese
"Efeito inotrópico negativo de exossomos plaquetários circulantes em pacientes com choque séptico: um novo mecanismo de disfunção miocárdica"
Keywords in Portuguese
CHOQUE SÉPTICO/fisiopatologia
CONTRAÇÃO MIOCÁRDICA
PLAQUETAS/secreção
SEPSE/fisiopatologia
Abstract in Portuguese
Um estudo prévio demonstrou em pacientes com choque séptico a presença de exossomos plasmáticos. Nossa hipótese é que exossomos circulantes poderiam contribuir para a disfunção contrátil da sepse. Foi colhido sangue de 55 pacientes com choque séptico. A incubação de corações isolados com exossomos de pacientes sépticos reduziu significantemente as derivadas da pressão ventricular e aumentou as concentrações de nitrato no miocárdio. A exposição de músculos papilares a exossomos reduziu a tensão desenvolvida. Concluímos que exossomos de pacientes sépticos induzem disfunção inotrópica em corações isolados e músculos papilares, possivelmente contribuindo para a disfunção miocárdica da sepse.
Keywords in English
BLOOD PLATELETS
MYOCARDIAL CONTRACTION
SEPSIS/physiopathology
SHOCK SEPTICS/physiopathology
Abstract in English
A previous report identified in plasma of septic shock patients the presence of exosomes. We hypothesized that circulating exosomes in sepsis could contribute to inotropic dysfunction. We collected blood samples from 55 patients with septic shock. Incubation of isolated heart preparations with exosomes induced a significant decrease in the derivatives of ventricular pressure and increased myocardial nitrate content. Exposure of isolated rat papillary muscles to exosomes reduced developed tension. We conclude that exosomes from septic patients induce myocardial dysfunction in isolated heart and papillary muscle preparations. Thus, they may contribute to myocardial dysfunction of sepsis.
 
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Publishing Date
2005-10-25
 
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