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Doctoral Thesis
DOI
10.11606/T.5.2008.tde-05112008-142800
Document
Author
Full name
Paolo José Cesare Biselli
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Martins, Milton de Arruda (President)
Jardim, José Roberto de Brito
Queluz, Thais Helena Abrahão Thomaz
Teixeira, Lisete Ribeiro
Tibério, Iolanda de Fátima Lopes Calvo
Title in Portuguese
Efeito da exposição à fumaça de cigarro e ao resíduo de óleo diesel (ROFA) em pulmões de camundongos C57/BI6
Keywords in Portuguese
Camundongos
Doença pulmonar obstrutiva crônica/fisiopatologia
Enfisema pulmonar
Poluição ambiental
Tabaco
Abstract in Portuguese
Vários mecanismos que participam do desenvolvimento da DPOC (Doença Pulmonar Obstrutiva Crônica) não são ainda bem esclarecidos. Neste estudo, expusemos camundongos C57/Bl6, por 2 meses, à fumaça de cigarro e/ou à ROFA (resíduo de óleo diesel). Os animais expostos à fumaça de cigarro desenvolveram aumento da resistência de grandes vias aéreas, provavelmente por espessamento da sua parede, resultante de alterações nas células epiteliais. Estes animais também desenvolveram enfisema inicial, com distensão de espaços aéreos em algumas regiões pulmonares. Não houve recrutamento de células inflamatórias, alteração de fibras elásticas ou colágenas ou aumento do estresse oxidativo, medido pelo Isoprostano 8. Este trabalho sugere que há uma lesão pulmonar inicial que se caracteriza por alterações nas células epiteliais e algum grau de enfisema, que pode ser mediado pelas próprias células epiteliais
Title in English
Effects of the exposure to cigarette smoke and residual oil fly ash (ROFA) in lungs of C57/Bl6 mice
Keywords in English
Chronic obstructive/physiopathology
Environmental pollution
Mice
Pulmonary disease
Pulmonary emphysema
Tobacco
Abstract in English
Many of the mechanisms leading to CPOD (Chronic Pulmonary Obstructive Disease) are not completely understood. In the present study, we exposed C57/Bl6 mice, for two months, to cigarette smoke and/or ROFA (Residual Oil Fly Ash). Animals exposed to cigarette smoke had an increased in proximal airways resistance, probably due to the thickening of airways walls that followed changes in epithelial cells. These animals also had a small degree of emphysema, once air spaces enlargement could be noticed in circumscribed lung areas. We observed no inflammatory cells recruitment, elastic or collagen fibers deposition or increases in oxidative stress, measured by staining Isoprotane8. This study shows an early stage of the CPOD development, in which we can detect changes in epithelial cells and a small degree of emphysema, which could be mediated by these same epithelial cells
 
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PaoloJCBiselli.pdf (2.18 Mbytes)
Publishing Date
2008-11-17
 
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