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Doctoral Thesis
DOI
https://doi.org/10.11606/T.5.2007.tde-21082007-115356
Document
Author
Full name
Walfredo Cherubini Fogaça
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Friedhofer, Henri (President)
Alonso, Nivaldo
Corsi, Rosangely de Cassia Cavanha
Daud, Eduardo Dib
Gemperli, Rolf
Title in Portuguese
Análise da integração do aloenxerto ósseo de crânio criopreservado e irradiado, adicionado de medula óssea autógena: estudo experimental em coelhos
Keywords in Portuguese
Bancos de ossos
Células-tronco
Coelhos
Crânio
Transplante de medula óssea
Transplante homólogo
Transplante ósseo
Abstract in Portuguese
Buscando alternativas ao enxerto ósseo autógeno para reconstruções craniofaciais, propõe-se a utilização de aloenxerto ósseo de crânio criopreservado, irradiado e enriquecido com medula óssea autógena.Vinte e um coelhos foram sacrificados e tiveram seus ossos parietais retirados, criopreservados e irradiados com irradiação gama em dose de 50kGy. Os aloenxertos foram implantados em defeitos nos crânios de vinte e um receptores. À esquerda implantava-se o aloenxerto ósseo puro e à direita o aloenxerto adicionado de medula óssea autógena. Os coelhos foram sacrificados em duas, cinco e dez semanas e os enxertos submetidos à análise macroscópica e histomorfométrica. Todos os enxertos apresentavam-se fixos ao leito. Os parâmetros histomorfométricos não mostraram diferenças estatisticamente significante.
Title in English
Deep frozen, irradiated calvarial bone allograft added with autogenous bone marrow incorporation analysis. Experimental study in rabbits
Keywords in English
Bone banks
Bone marrow transplantation
Bone transplantation
Rabbits
Skull
Stem cells
Transplantation homologous
Abstract in English
Searching for alternatives to autogenous bone graft in craniofacial reconstructions, it is proposed deep-frozen, irradiated calvarial bone allograft added with autogenous bone marrow utilization. Twenty and one rabbits were sacrificed and their parietal bones harvest, deep-frozen and gamma irradiated with 50kGy. The allografts were implanted in twenty one other rabbits. At left side only allograft were placed, at right side were put allografts added with autogenous bone marrow. The animals were sacrificed in two, five and ten weeks. Macroscopical examination showed all grafts fixed at the host bone, the histomorphometric analysis did not showed significant statistical differences between the left and right sides.
 
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walfredocfogaca.pdf (1.75 Mbytes)
Publishing Date
2007-08-22
 
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