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Master's Dissertation
DOI
10.11606/D.5.2006.tde-11042006-163614
Document
Author
Full name
André Guerra de Almeida
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Faintuch, Joel (President)
Andreollo, Nelson Adami
Pinto Junior, Paulo Engler
Title in Portuguese
"Correlações entre achados laboratoriais e doença hepática gordurosa não alcoólica em pacientes portadores de obesidade mórbida"
Keywords in Portuguese
Biópsia
Fígado gorduroso
Gastroplastia
Obesidade mórbida
Síndrome X metabólica
Testes de função hepática
Abstract in Portuguese
Devido a controvérsias sobre a freqüência, diagnóstico e possibilidade de progressão para doença crônica da degeneração gordurosa do fígado em portadores de obesidade mórbida, planejou-se uma investigação retrospectiva em pacientes candidatos à cirurgia bariátrica. Foram analisados 60 indivíduos com indicação de gastroplastia com derivação intestinal em Y de Roux. Os pacientes foram submetidos a questionário clínico, provas bioquímicas e posteriormente, à biópsia hepática intraoperatória. A freqüência de EHNA e esteatose hepática foi elevada, e detectou-se 5% de cirrose. Na análise univariada houve correlação de diversos testes bioquímicos com as enzimas hepáticas. Na análise multivariada a albumina foi a variável determinante; apesar de seu debilitado valor preditivo. Nestas condições, apenas a avaliação histológica configura-se como critério definitivo para diagnóstico e acompanhamento desta população
Title in English
Correlations between biochemical findings and nonalcoholic fatty liver disease (NAFLD) in morbidly obese patients
Keywords in English
Biopsy
Fatty liver
Gastroplasty
Liver function tests
Metabolic syndrome X
Obesity morbid
Abstract in English
Because of controversies about frequency, diagnosis and possibility of progression toward chronic disease of fatty degeneration of the liver in morbidly obese patients, a retrospective study was done in patients who underwent bariatric surgery. Sixty individuals with indication for gastroplasty with Roux-en-Y jejunal bypass were enrolled. They were submitted to clinical questionnaire, biochemistry tests and subsequently, intraoperative liver biopsy. Frequency of NASH and steatosis was high, and 5.0% suffered from cirrhosis. In univariate analysis there was correlation between various biochemical measurements and liver enzymes. In multivariate analysis only serum albumin was a determinant variable, with low predictive value. The histological grading system remains the definitive criterion for diagnosis and follow-up of this population
 
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Publishing Date
2006-04-12
 
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