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Doctoral Thesis
DOI
10.11606/T.5.2005.tde-03062005-155426
Document
Author
Full name
Sandro José Martins
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Takagaki, Teresa Yae (President)
Barbas, Carmen Silvia Valente
Sabbaga, Jorge
Santoro, Ilka Lopes
Tadokoro, Hakaru
Title in Portuguese
"Contribuição à avaliação prognóstica de pacientes com adenocarcinoma pulmonar avançado: estudo imunohistoquímico da expressão do fator 1 de transcrição tireoideano e da metaloproteinase 9"
Keywords in Portuguese
adenocarcinoma
análise de sobrevivência
imunohistoquímica/métodos
metaloproteínas
neoplasias pulmonares/patologia
Abstract in Portuguese
O valor prognóstico da expressão do Fator 1 de Transcrição Tireoideano (TTF-1) e da metaloproteinase-9 (MMP-9) foi avaliado em 51 pacientes com adenocarcinoma pulmonar avançado. Foram fatores de mau prognóstico: baixa capacidade funcional (P = 0,017), baixa expressão do TTF-1 (P = 0,001) e alta expressão da MMP-9 (P = 0,008). Identificaram-se três grupos de risco para mortalidade: baixo risco (TTF-1 > 40% e MMP-9 < 80%; sobrevida: 127,6 semanas), risco intermediário (TTF-1 < 40% ou MMP-9 > 80%; sobrevida: 39,0 semanas) e alto risco (TTF-1 < 40% e MMP-9 > 80%; sobrevida: 16,4 semanas). Com a detecção destes marcadores é possível a identificação de subgrupos de pacientes com prognósticos clinicamente distintos.
Title in English
Contribution to the prognostic assessment of patients with advanced lung adenocarcinoma: evaluation by immunohistochemical methods of thyroid transcription factor-1 and matrix metalloproteinase-9
Keywords in English
adenocarcinoma
immunohistochemistry/methods
lung neoplasms/pathology
metalloproteins
survival analysis
Abstract in English
The prognostic value of Thyroid Transcription Factor-1 (TTF-1) and Matrix Metalloproteinase-9 (MMP-9) tumor expression was evaluated in 51 patients with advanced lung adenocarcinoma. Poor performance status (P = 0.017), low TTF-1 (P = 0.001), and high MMP-9 (P = 0.008) were independent prognostic factors. There was three risk groups: low risk (TTF-1 > 40% and MMP-9 < 80%; median survival: 127.6 wk), intermediate risk (TTF-1 < 40% or MMP-9 > 80%; median survival: 39.0 wk), and high risk (TTF-1 < 40% and MMP-9 > 80%; median survival: 16.4 wk). Evaluation of TTF-1 and MMP-9 may allow us to identify different, clinically meaningful, prognostic groups of lung adenocarcinoma patients.
 
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Publishing Date
2005-08-03
 
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