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Master's Dissertation
DOI
https://doi.org/10.11606/D.5.2004.tde-24102005-151101
Document
Author
Full name
Simone Nascimento Fagundes
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2003
Supervisor
Committee
Koch, Vera Hermina Kalika (President)
Bastos, Herculano Dias
Vaisbich, Maria Helena
Title in Portuguese
"Levantamento da situação vacinal e avaliação sorológica para sarampo e varicela de crianças e adolescentes portadores de insuficiência renal crônica em tratamento conservador e dialítico"
Keywords in Portuguese
DIÁLISE/métodos
ESTUDOS TRANSVERSAIS
INSUFICIÊNCIA RENAL CRÔNICA/imunologia
INSUFICIÊNCIA RENAL CRÔNICA/terapia
PEDIATRIA
SARAMPO
TESTES SOROLÓGICOS/métodos
VACINA CONTRA SARAMPO
VACINA CONTRA VARICELA
VACINAÇÃO
VARICELA
Abstract in Portuguese
A infecção é causa de morbimortalidade no paciente com insuficiência renal crônica (IRC), facilitada pela uremia, que leva a resposta imune insuficiente, inclusive após a vacinação. Foram avaliadas a situação vacinal e a presença de anticorpos para sarampo e varicela, de 83 crianças e adolescentes com IRC. A adesão dos pacientes às vacinas foi BCG 100%, poliomielite 98,8%, DPT 97,6%, sarampo monovalente 96,4%, tríplice viral 88%, hepatite B 68,7%. Ausência de anticorpos para sarampo e varicela ocorreu em 14,5% e 26,5% dos pacientes. A susceptibilidade ao sarampo em vacinados, predominou acima de seis anos (P < 0,00001) e à varicela (infecção natural) abaixo de sete anos (P < 0,001). O renal crônico pediátrico deve receber esquema vacinal amplo, com avaliação periódica de títulos de anticorpos
Title in English
Immunization status analysis and evaluation of antibody titers against measles and varicella in 83 chronic renal failure children and adolescents in conservative and dialytic therapy
Keywords in English
CHICKENPOX
CHICKENPOX VACCINE
CROSS-SECTIONAL STUDIES
DIALYSIS/methods
KIDNEY FAILURE CHRONIC/immunology
KIDNEY FAILURE CHRONIC/therapy
MEASLES
MEASLES VACCINE
PEDIATRICS
SEROLOGIC TESTS/methods
VACCINATION
Abstract in English
Infections are a cause of morbidity and mortality in chronic renal failure (CRF) patients, facilitated by uremia, which promotes a deficient immune response and hinders response to vaccination. We evaluated the immunization status and antibody titers against measles and varicella in 83 CRF children and adolescents. Adhesion to vaccination was 100% BCG, 98,8% poliomyelitis, 97,6% DPT, 96,4% measles, 88% MMR, 68,7% hepatitis B. Non-detectable antibodies against measles and varicella occurred in 14,5% and 26,5% patients. Susceptibility to measles, after vaccination, increased above 6 years (P < 0,00001) and to varicella (natural infection), below seven years of age (P < 0,001). Pediatric CRF patients should receive a robust immunization program with periodic antibody titer assessment
 
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Publishing Date
2005-10-25
 
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