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Master's Dissertation
DOI
10.11606/D.5.2005.tde-17022006-132205
Document
Author
Full name
Marcia Datz Abadi
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Camargo, Olavo Pires de (President)
Odone Filho, Vicente
Petrilli, Antonio Sergio
Title in Portuguese
"Análise imunohistoquímica do osteossarcoma em pacientes com e sem metástases e sua correlação prognóstica"
Keywords in Portuguese
ANTÍGENO NUCLEAR DE CÉLULA EM PROLIFERAÇÃO
GLICOPROTEÍNA P
IMUNOHISTOQUÍMICA/métodos
OSTEOSARCOMA/patologia
PROGNÓSTICO
PROTEÍNA P53
PROTEÍNA PROTO-ONCOGÊNICA C-KIT
RECEPTOR ERBB-2
Abstract in Portuguese
As proteínas p53, MDM-2, c-Kit, ErbB-2, PCNA e p-glicoproteína foram estudadas em 42 amostras de osteossarcoma ao diagnóstico, através da técnica de imunohistoquímica, e foram correlacionados estes achados com o prognóstico destes pacientes. O p-53 foi positivo em 23,1% (9/39), PCNA em 71,4% (25/35), p-glicoproteína em 40,5% (15/37), MDM-2 em 34,8% (8/23), c-kit em 67,6% (25/37) e ErbB-2 em 17,9% (7/39). Na análise univariada, a presença de metástases ao diagnóstico, a positividade de p53 e ErbB-2 influenciaram o prognóstico individualmente, entretanto, na análise multivariada, a presença de metástase ao diagnóstico revelou-se o único fator de prognóstico estatisticamente significante
Title in English
Immunohistochemistry analysis of osteosarcoma in patients with and without metastasis and its prognosis correlation
Keywords in English
IMMUNOHISTOCHEMISTRY/methods
OSTEOSARCOMA/pathology
P-GLYCOPROTEIN
PROGNOSIS
PROLIFERATING CELL NUCLEAR ANTIGEN
PROTEIN p53
PROTO-ONCOGENE PROTEIN C-KIT
RECEPTOR ERBB-2
Abstract in English
We study, by imunohistochemistry technique, the proteins p53, MDM-2, c-Kit, ErbB-2, PCNA and p-glycoprotein in samples of osteosarcoma tumors at diagnosis and its correlation with the prognosis of this patients. The p-53 was positive in 23,1% (9/39), PCNA in 71,4% (25/35), p-glycoprotein in 40,5% (15/37), MDM-2 in 34,8% (8/23), c-kit in 67,8%(25/37) and ErbB-2 in 17,9% (7/39) of the samples. In the univariate analysis, the presence of metastasis at diagnosis, the positivity of p-53 and ErbB-2 influenced the prognosis individually, otherwise, in the multivariate analysis, the presence of metastasis at diagnosis was the only prgnostic factor statistically significant
 
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Publishing Date
2006-02-24
 
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