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Doctoral Thesis
DOI
https://doi.org/10.11606/T.5.2005.tde-14102014-161625
Document
Author
Full name
Arnóbio Rocha Oliveira
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Barros Filho, Tarcisio Eloy Pessoa de (President)
Franco, José Sérgio
Hernandez, Arnaldo Jose
Oliveira, Reginaldo Perilo
Puertas, Eduardo Barros
Title in Portuguese
Efeitos do tempo da descompressão medular no traumatismo raquimedular: estudo experimental em ratos
Keywords in Portuguese
Descompressão cirúrgica/métodos
Medula espinhal/anatomia & histologia
Potencial evocado motor
Ratos wistar
Traumatismo da medula espinhal/cirurgia
Abstract in Portuguese
Com o objetivo de avaliar os efeitos do tempo da descompressão medular em 50 ratos, machos, da raça Wistar, criou-se um modelo experimental de compressão medular através da passagem de uma fita de tecido (cetim), que reduz em 30% o diâmetro do canal vertebral na região da coluna torácica após laminectomia (TIX E TX). Os animais foram distribuídos em cinco grupos com 10 ratos cada, sendo: grupo A, controle da técnica de exposição medular atraumática, sem lesão; grupo B, submetidos à compressão medular, seguida de descompressão cinco minutos após a lesão; nos grupos C e D, realizou-se o mesmo procedimento do grupo B, porém a descompressão ocorreu 24 e 72 horas após a compressão, respectivamente; os ratos do grupo E sofreram compressão, sem descompressão até o fim do experimento na quarta semana, quando os 50 ratos foram submetidos à eutanásia. Todos os animais com compressão (B, C, D e E) apresentaram paraplegia no pós-operatório imediato. A recuperação neurológica foi avaliada através do potencial evocado motor, da escala BBB de capacidade locomotora e do exame anatomopatológico do sítio da lesão. Observou-se relação direta entre o potencial de recuperação neurológica e o tempo da descompressão medular nos três métodos de avaliação
Title in English
Effects of medullary decompression time in spinal cord injury: experimental study in rats
Keywords in English
Decompression surgical/methods
disorders of the spinal cord/surgery
Evoked Potentials motor
Rats Wistar
Spinal cord/anatomy and histology
Abstract in English
With the objective of evaluating the effects of medullary decompression time in 50 male Wistar rats, an experimental model of medullary compression was created, through the insertion of a satin tape, which reduces in 30% the diameter of the vertebral canal at the region of the thoracic column after laminectomy (TIX and TX). The animals were distributed in five groups with 10 rats each, as follows: group A: control of the technique of atraumatic medullary exposure, with no lesion; group B, submitted to medullary compression, followed by decompression five minutes after the lesion; groups C and D underwent the same procedure, but decompression was performed 24 and 72 hours after compression, respectively; and finally, rats from group E underwent compression without decompression up to the end of the experiment on the 4th week, when all 50 rats were euthanized. All animals submitted to compression (groups B, C, D and E) presented paraplegia in the immediate post-operative period. The neurological recovery was evaluated through the motor-evoked potential of the BBB scale of locomotor capacity and anatomopathological examination of the lesion site. A direct correlation between the neurological recovery potential and time of medullary decompression was observed at the three evaluation methods
 
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Publishing Date
2014-10-14
 
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