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Doctoral Thesis
DOI
10.11606/T.5.2006.tde-29032006-091248
Document
Author
Full name
Patricia Andreucci Gomes
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Cuce, Luiz Carlos (President)
Aoki, Valeria
Chiacchio, Nilton Di
Landman, Gilles
Oliveira, Zilda Najjar Prado de
Title in Portuguese
"Líquen escleroso vulvar: estudo dos marcadores Ki-67 e p53 antes e após o tratamento com clobetasol a 0,05%, testosterona a 2% e um placebo"
Keywords in Portuguese
Antígeno Ki-67
Corticosteróides
Doenças da vulva
Líquen escleroso e atrófico
Marcadores biológicos
Proteína p53
Testosterona
Abstract in Portuguese
O líquen escleroso vulvar é uma doença crônica e benigna, porém apresenta um potencial de malignização para o carcinoma de células escamosas de vulva. Foram estudadas trinta doentes com líquen escleroso vulvar, divididas em três grupos, que fizeram uso tópico de propionato de clobetasol a 0,05%, testosterona a 2% e um placebo, para avaliar a evolução dos sintomas e o comportamento das células marcadas com o anticorpo Ki-67 e a proteína p53 antes e após os tratamentos. Observou-se melhora dos sintomas clínicos com o uso do clobetasol e da testosterona, que foi estatisticamente superior ao placebo (p<0,01). Observou-se diminuição significante das células marcadas com Ki-67 após o tratamento das doentes com o clobetasol (p<0,01) e com a testosterona (p<0,02). Enquanto, nas doentes que utilizaram placebo, observou-se um aumento do Ki-67. Em relação à análise das células marcadas com a proteína p53 também observou-se diminuição significante após o tratamento com o clobetasol (p<0,01) e com a testosterona (p<0,01). Enquanto no grupo placebo observou-se um aumento do p53. Quando se compara a variação do p53 entre os grupos clobetasol, testosterona e placebo observou-se uma diminuição do p53 estatisticamente superior (p<0,001) nas doentes que utilizaram clobetasol. Assim, os resultados mostram uma redução dos marcadores celulares após os tratamentos, e com o p53 a diminuição foi estatisticamente maior no grupo que utilizou clobetasol, sugerindo a eficácia desse tratamento
Title in English
Vulvar lichen sclerosus: a study of markers Ki-67 and p53 before and after the treatment with clobetasol at 0.05%, testosterone at 2% and a placebo
Keywords in English
Adrenal cortex hormones
Biological markers
Ki-67 Antigen
Lichen sclerosus et atrophicus
Protein p53
Testosterone
Vulvar diseases
Abstract in English
Vulvar Lichen Sclerosus consists of a benign chronic disease, however featuring a malignant potential for vulvar squamous cell carcinoma. The present study targeted 30 patients diagnosed Vulvar Lichen Sclerosus, divided in three groups, and who made topical use of clobetasol propionate at 0.05%, testosterone at 2% and a placebo, so as to assess the evolution of the symptoms and the behavior of the cells marked with antibody Ki-67 and protein p53, before and after the treatments. The administration of clobetasol and testosterone has proven effective in the management of the clinical symptoms, which turned out to be statistically higher than the placebo (p<0.01). The number of cells marked with Ki-67 decreased significantly patients treated with clobetasol (p<0.01) and testosterone (p<0.02), while the number of such cells increased in those patients who made use of the placebo. The number of cells marked with protein p53 also decreased significantly after the treatment with clobetasol (p<0.01) and testosterone (p<0.01), whereas the placebo group revealed an increased p53. When comparing the decrease of the p53 in the clobetasol, testosterone and placebo groups, we noted a decrease of the p53 statistically higher (p<0.001) in patients under clobetasol; suggesting a reduction in the cellular markers after the treatment. As for the p53, the decrease was statistically higher in the group under clobetasol, suggesting the efficacy of the treatment.
 
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referencias.pdf (49.26 Kbytes)
tese.pdf (153.50 Kbytes)
Publishing Date
2006-04-17
 
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