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Master's Dissertation
DOI
10.11606/D.5.2005.tde-04012006-100321
Document
Author
Full name
Patrícia Aparecida Ferreira de Oliveira
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Sanches Junior, Jose Antonio (President)
Pereira, Juliana
Zerbini, Maria Claudia Nogueira
Title in Portuguese
"Estudo do perfil morfológico e imunofenotípico dos linfócitos do sangue periférico de pacientes portadores de micose fungóide nas fases precoce e avançada"
Keywords in Portuguese
IMUNOFENOTIPAGEM
LINFÓCITOS/citologia
LINFÓCITOS/sangue
MICOSE FUNGÓIDE/diagnóstico
MICOSE FUNGÓIDE/sangue
Abstract in Portuguese
Com o objetivo de avaliar os linfócitos do sangue periférico na micose fungóide, foram realizados hemograma e imunofenotipagem por citometria de fluxo de 40 doentes e de 26 indivíduos saudáveis. Verificou-se que células de Sézary acima de 7% e linfócitos pleomórficos acima de 24% estiveram presentes apenas na doença. Alterações quantitativas, qualitativas, perda de marcadores imunofenotípicos e presença de populações linfocitárias com tamanhos distintos, na citometria, foram verificadas nos doentes mais precocemente que alterações numéricas e morfológicas do hemograma
Title in English
Study of morphologic and immunophenotypic profile lymphocytes on peripheral blood from patients with mycosis fungoides in early and advanced stages
Keywords in English
IMMUNOPHETYPING
LYMPHOCYTES/blood
LYMPHOCYTES/cytology
MYCOSIS FUNGOIDES/blood
MYCOSIS FUNGOIDES/diagnosis
Abstract in English
Aiming to evaluate peripheral blood lymphocytes in mycosis fungoides, we have performed hemogram and immunophenotyping by flow cytometry in about 40 patients and 26 healthy people. We have noticed that only diseased patients presented Sézary cells higher than 7% and pleomorphic cells higher than 24%. Quantitative and qualitative changes, loss of immunophenotyping markers and the presence of lymphocytes populations with different size, on flow cytometry, were firstly verified on patients rather than numeric and morphologic changes in
 
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Publishing Date
2006-01-12
 
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