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Doctoral Thesis
DOI
https://doi.org/10.11606/T.5.2007.tde-20022009-133403
Document
Author
Full name
Marly Maria Uellendahl Lopes
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Rochitte, Carlos Eduardo (President)
Fernandes, Juliano de Lara
Salemi, Vera Maria Cury
Szarf, Gilberto
Victor, Edgar Guimarães
Title in Portuguese
Detecção de fibrose miocárdica pela ressonância magnética cardiovascular em portadores de doença de Chagas: correlação com as formas clínicas e prognóstico
Keywords in Portuguese
Doença de Chagas
Fibrose
Imagem por ressonância magnética
Prognóstico
Abstract in Portuguese
INTRODUÇÃO: A doença de Chagas (DC) persiste como um importante problema de saúde na América Latina, onde o envolvimento cardíaco é responsável pela elevada morbidade e mortalidade. A identificação dos pacientes de maior risco representa, portanto, um grande desafio. A ressonância magnética cardiovascular (RMC) é uma metodologia de elevada acurácia na avaliação da morfologia e da função ventricular e permite a detecção da fibrose miocárdica pela técnica do realce tardio, podendo ser útil na estratificação de risco dos pacientes chagásicos. OBJETIVOS: Avaliar as características morfológicas e funcionais dos ventrículos esquerdo e direito nas formas clínicas da DC; avaliar a fibrose miocárdica pela RMC e sua relação com as formas clínicas da DC; investigar o valor prognóstico da fibrose miocárdica, através de sua correlação com o escore de Rassi. MÉTODOS: Foram estudados 39 pacientes, sendo 20 do sexo masculino. A população de pacientes foi dividida em dois grupos: com cardiopatia aparente (CCA) e sem cardiopatia aparente (SCA). Todos os pacientes foram submetidos a estudo de RMC para avaliação morfológica e funcional; e detecção da fibrose miocárdica. Visando à obtenção do escore de Rassi, os pacientes realizaram avaliação clínica, eletrocardiograma, radiografia do tórax, ecodopplercardiograma e eletrocardiografia dinâmica de 24 horas (Holter). Os pacientes foram classificados, de acordo com o escore de Rassi, em: de baixo, de médio e de alto risco, e foi realizada a correlação desse escore com os parâmetros obtidos pela RMC. RESULTADOS: Os aspectos morfológicos e funcionais do VE apresentaram uma diferença significante entre as formas clínicas estudadas, e a quantificação de fibrose miocárdica na DC apresentou uma forte correlação com o escore de Rassi (r=0,76 p<0,001). CONCLUSÕES: O ventrículo esquerdo apresentou comprometimento morfológico e funcional no grupo com cardiopatia aparente; a extensão da fibrose miocárdica foi maior no grupo com cardiopatia aparente; a quantificação de fibrose miocárdica pela RMC apresentou forte correlação com o escore de Rassi, denotando o valor prognóstico da RMC nesse grupo de paciente chagásico
Title in English
Detection of myocardial fibrosis by cardiovascular magnetic resonance imaging in patients with Chagas disease: correlation with clinical presentation and risk stratification
Keywords in English
Chagas disease
Fibrosis
Magnetic resonance imaging
Prognosis
Abstract in English
INTRODUCTION: Chagas disease (CD) still remains an important health problem in Latin America. One of the major challenges is to identify high risk patients. Considering that magnetic resonance imaging (MRI) has a very high accuracy to assess morphology and ventricular function and that myocardial delayed enhancement (MDE) technique is well established to detect myocardial fibrosis, we believe that MRI may have an important role to stratify patients with CD. OBJECTIVES: Evaluate morphological and functional ventricular characteristics, as well as the extent of myocardial fibrosis (MF) in patients with Chagasdisease, by magnetic resonance imaging (MRI); and search the prognostic value of myocardial fibrosis detected by MRI, comparing these findings with the recently developed Rassi`s score. METHODS: 39 patients were evaluated (male sex = 20), divided in two main groups: a) with apparent cardiomyopathy (AC) and without apparent cardiomyopathy (WAC). All patients were submitted to MRI, using the technique of myocardial delayed enhancement (MDE) and the results were compared with the Rassi`s score (RS), which was obtained by analyzing the following parameters: 12-lead electrocardiogram, chest x-ray, echodopplercardiography and 24-hour dynamic electrocardiography (Holter). Patients were stratified as belonging to the low, medium or high risk group, and then each one was compared with data obtained by MRI. RESULTS: Regarding the morphological and functional analysis, significant differences were observed in both groups (p< 0.001). Furthermore, there was a strong correlation between the extent of myocardial fibrosis and the Rassi`s score (r= 0.76). CONCLUSIONS: MRI is an important technique in the evaluation of patients with CD, stressing morphological and functional differences in all clinical presentations. The strong correlation with the Rassi`s score and the extent of myocardial fibrosis detected by MRI, emphasizes its role in the prognostic stratification of patients with CD
 
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2009-03-12
 
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