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Doctoral Thesis
DOI
https://doi.org/10.11606/T.5.2003.tde-18102005-153528
Document
Author
Full name
Marcus Vinícius Bolívar Malachias
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2003
Supervisor
Committee
Krieger, Eduardo Moacyr (President)
Cunha, Roberto de Sá
Martinez Filho, Eulogio Emilio
Nussbacher, Amit
Santos, Robson Augusto Souza dos
Title in Portuguese
"A rigidez arterial e o barorreflexo em diabéticos do tipo 2"
Keywords in Portuguese
BARORREFLEXO
COMPLACÊNCIA
DIABETES MELLITUS NÃO INSULINO-DEPENDENTE/complicações
Abstract in Portuguese
Avaliou-se a velocidade da onda de pulso (VOP) carótido-femoral (CF) e carótido-radial (CR), por meio de técnica não-invasiva, em 14 indivíduos diabéticos do tipo 2 normotensos, A sensibilidade do barorreflexo (SBR) foi avaliada pela manobra de Valsalva e por testes com nitroglicerina e fenilefrina, durante monitorização não-invasiva batimento-a-batimento da pressão arterial. Os resultados foram comparados aos obtidos em 13 indívíduos saudáveis pareados por idade, índice de massa corporal e sexo. O grupo diabetes apresentou maiores níveis de glicose de jejum e HbA1c. As VOP CF e CR foram mais elevadas no grupo diabetes. A SBR estava reduzida nos diabéticos, nos testes com nitroglicerina, fenilefrina e, no reflexo de taquicardia da fase II da manobra de Valsalva. O aumento da VOP CF foi significativamente correlacionado à redução da SBR. Os resultados demonstram que em diabéticos do tipo 2 há maior rigidez arterial e a SBR está reduzida. A SBR é inversamente correlacionada ao aumento da rigidez arterial
Title in English
Arterial stiffness and baroreflex sensitivity in individuals with type 2 diabetes
Keywords in English
BAROREFLEX
COMPLIANCE
DIABETES MELLITUS TYPE II/complications
Abstract in English
Fourteen normotensive diabetic subjects were submitted to carotid-femoral (CF) and carotid-radial (CR) pulse wave velocity (PWV) analysis by non-invasive automatic device. The baroreflex sensitivity (BRS) was evaluated by Valsalva manoeuvre, phenylephrine and nitroglycerin tests during non-invasive beat-to-beat blood pressure monitoring. The data were compared with those obtained in 13 age, body mass index and sex-matched healthy subjects. The diabetes group showed a higher fasting glucose level and HbA1c. The CF PWV and CR PWV were higher in diabetic patients. The BRS was impaired in diabetic individuals in nitroglycerine and phenylephrine tests and, also, in the tachycardic reflex in phase II of Valsalva manoeuvre. The increase of CF PWV was significantly correlated to the decrease of BRS. The data demonstrated that, in diabetic normotensive individuals, arterial stiffness is increased and the BRS is impaired. The BRS is inverselly correlated to increase of aortic stiffness
 
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marcusviniciustese.pdf (705.82 Kbytes)
Publishing Date
2005-12-05
 
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