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Doctoral Thesis
DOI
https://doi.org/10.11606/T.5.2007.tde-11032008-162532
Document
Author
Full name
Raimundo Marques do Nascimento Neto
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Krieger, Jose Eduardo (President)
Franco, Roberto Jorge da Silva
Giorgi, Dante Marcelo Artigas
Nobre, Moacyr Roberto Cuce
Tavares, Agostinho
Title in Portuguese
Estudo da associação dos polimorfismos da ECA e do AGT e fenótipos de risco cardiovascular em amostra feminina de Ouro Preto
Keywords in Portuguese
Doenças cardiovasculares
Fatores de risco
Fenótipo
Hipertensão/epidemiologia
Mulheres
Sistema renina-angiotensina/genética
Abstract in Portuguese
Estudamos a amostra das ouropretanas com prevalência de hipertensão arterial de (52,7%). O objetivo foi descrever os fenótipos sistólico, diastólico e pressão de pulso e correlacionar as variantes genética da ECA e AGT. Os dados sugerem que a prevalência de hipertensão entre elas estão associadas a idade, classe social, escolaridade, hiperglicemia, circunferência da cintura abdominal, e perfil lipídico. O alelo T foi significante com glicemia {p < 0,02 (OR = 2,2)} e cor preta {p < 0,002 (OR = 2,7)} o alelo D com idade {p < 0,01 (OR = 2,2)} e HDL {p < 0,0007 (OR= 1,5)}. O genótipo DD com a idade {p < 0,03 (OR = 0,7)} e HDL {p < 0,008 (OR = 2,0)}. A influência das variantes genéticas da ECA e do AGT tiveram pouco efeito sobre os fenótipos de pressão arterial, mas influenciaram os níveis de colesterol HDL e a glicemia, respectivamente.
Title in English
Study of the associations of the ECA and AGT polymorphism and cardiovascular risk phenotypes in a female sampling in Ouro Preto
Keywords in English
Cardiovascular dseases
Hypertension/epidemiology
Phenotype
Renin-angiotensin system/genetics
Risk factors
Women
Abstract in English
We studied the sample of women from Ouro Preto with a prevalence of arterial hypertension of (52,7%). The objective was to describe systolic, diastolic and pulse pressure phenotypes and correlate the ECA and AGT genetic variants. The data suggests that the prevalence of hypertension among them is related to age, social class, schooling, hyperglycemia, abdominal and lipidic profile. The T allele showed significance with glycemia {p < 0.02 (OR = 2.2) and color black {p < 0.002 (OR = 2.7)}. The D allele with age {p < 0.01 (OR = 2.2)} and HDL {p < 0.0007 (OR=1.5)}. The DD genotype with age {p < 0.03 (OR = 0.7)} and HDL {p
 
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RMNascimentoNeto.pdf (2.33 Mbytes)
Publishing Date
2008-03-17
 
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