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Doctoral Thesis
DOI
https://doi.org/10.11606/T.5.2016.tde-06062016-111905
Document
Author
Full name
Isabel Barbara Lopes dos Santos Figueira
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2016
Supervisor
Committee
Vinagre, Carmen Guilherme Christiano de Matos (President)
Bertolami, Marcelo Chiara
Dourado, Paulo Magno Martins
Irigoyen, Maria Claudia Costa
Title in Portuguese
Efeitos  da vitamina E associada a nanopartículas lipídicas no remodelamento cardíaco, em ratos infartados
Keywords in Portuguese
Ecocardiografia
Fibrose
Hipertrofia
Infarto do miocárdio
Ratos wistar
Remodelação ventricular
Vitamina E
Abstract in Portuguese
Do ponto de vista clínico, o remodelamento ventricular está associado a um pior prognóstico. Pacientes com remodelamento já diagnosticado, ou com alto risco de desenvolvê-lo, devem ser tratados de forma intensiva, a fim de prevenir, atenuar ou mesmo reverter esse processo. O objetivo do presente estudo foi investigar os efeitos da vitamina E associada a nanopartículas lipídicas no remodelamento cardíaco, em ratos. Medidas ecocardiográficas foram determinadas 24 horas pós infarto e seis semanas após tratamento. Cortes teciduais do coração foram submetidos a coloração com Hematoxilina eosina e Picrosirius red. Duas regiões distintas do ventrículo esquerdo remotas ao infarto foram examinadas: subendocárdica e não subendocárdica. A extensão do infarto, o diâmetro dos miócitos, a fração de variação da área e o índice de expansão do ventrículo esquerdo foram determinados. No ecocardiograma observamos que os grupos infartados apresentaram um aumento no diâmetro diastólico e sistólico, uma diminuição da fração de encurtamento e da fração de variação da área quando comparados ao grupo controle. Na análise morfométrica, foi observado que nos animais infartados houve um aumento do diâmetro dos miócitos, da expansão do ventrículo esquerdo e da fração de volume do colágeno, principalmente na região subendocárdica, quando comparado ao grupo controle. A vitamina E associada a nanopartículas lipídicas, não apresentou efeitos protetores e nem atenuantes no remodelamento cardíaco nesse modelo experimental
Title in English
Effects of vitamin E associated to lipid nanoparticles in the cardiac remodeling, in infarcted rats
Keywords in English
Echocardiography
Fibrosis
Hypertrophy
Myocardial infarction
Ventricular remodeling
Vitamin E
Wistar rats
Abstract in English
From a clinical point of view, the ventricular remodeling is associated with a worse prognosis. Patients already diagnosed remodeling or at high risk of developing it, should be treated intensively to prevent, attenuate or even reverse this process. The aim of this study was to investigate the effects of vitamin E associated with lipid nanoparticles on cardiac remodeling in rats. Echocardiographic measurements were determined 24 hours post infarction and six weeks after treatment. Heart tissue sections were stained with Hematoxylin eosin and Picrosirius red. Two distinct regions of the left ventricle, remote to infarction, were examined: subendocardial and not subendocardial. The extent of the infarction, the diameter myocytes, collagen volume fraction and expansion index of the left ventricle were determined. On echocardiogram we observed that infarcted groups showed an increase in diastolic and systolic diameter and decreased in fractional shortening and the area variation fraction when compared to the control group. In the morphometric analysis, was observed that in infarcted animals there was an increase in the diameter myocytes, the expansion of the left ventricle and collagen volume fraction, especially in the subendocardial region, when compared to the control group. Vitamin E associated to lipid nanoparticles, showed no protective nor attenuated effects on cardiac remodeling in this experimental model
 
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Publishing Date
2016-06-06
 
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