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Doctoral Thesis
DOI
10.11606/T.5.2004.tde-03062005-143610
Document
Author
Full name
Isa Dietrich
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2004
Supervisor
Committee
Rodrigues, Consuelo Junqueira (President)
Andrade, Fernando Antonio Gomes de
Azeka, Estela
Cruz, Gilvani Azor de Oliveira e
Maria, Durvanei Augusto
Title in Portuguese
"Influência da composição de carreador biodegradável na viabilidade do implante de células mesenquimais indiferenciadas do tecido adiposo humano"
Keywords in Portuguese
CÉLULAS DO TECIDO CONJUNTIVO
CÉLULAS ESTROMAIS/transplante
CÉLULAS PRIMITIVAS/classificação
CÉLULAS PRIMITIVAS/transplante
ENGENHARIA BIOMÉDICA
LESÕES DOS TECIDOS MOLES/terapia
NEOVASCULARIZAÇÃO FISIOLÓGICA
PROCEDIMENTOS CIRÚRGICOS RECONSTRUTIVOS
SOBREVIVÊNCIA DE TECIDOS
TRANSPLANTE DE CÉLULAS-TRONCO
TRANSPLANTE DE TECIDOS
TRANSPLANTES
Abstract in Portuguese
Células mesenquimais indiferenciadas humanas foram obtidas por digestão enzimática e centrifugação do produto de lipoaspiração, expandidas in vitro, e implantadas no tecido subcutâneo de camundongos atímicos. No grupo I, cada animal recebeu o implante de uma membrana de 0,25cm2 de ácido glicólico e carbonato de trimetileno semeada com 1 x 106 destas células .No grupo II, cada um recebeu a injeção de 0,2ml de gel de ácido hialurônico reticulado contendo o mesmo número destas células. Com três semanas de implante, células humanas e vasos foram identificados nos dois carreadores. Entretanto, com oito semanas, somente no gel de ácido hialurônico as células humanas e os vasos estavam presentes
Title in English
Influence of scaffold composition in the viability of implantation of human adipose derived undifferentiated mesenchymal cells
Keywords in English
BIOMEDICAL ENGINEERING
CONNECTIVE TISSUE CELLS
NEOVASCULARIZATION PHYSIOLOGIC
RECONSTRUCTIVE SURGICAL PROCEDURES
SOFT TISSUE INJURIES/therapy
STEM CELL TRANSPLANTATION
STEM CELL/classification STEM CELL/transplantation
STROMAL CELLS/transplantation
TISSUE SURVIVAL
TISSUE TRANSPLANTATION
TRANSPLANTS
Abstract in English
Human undifferentiated mesenchymal cells were obtained by enzymatic digestion and centrifugation of the product of liposuction. These cells were expanded, in vitro, and implanted subcutaneously in athymic mice. In group I, each animal received the implant of a 0,25cm2 membrane of glycolic acid and trimethylene carbonate, seeded with 1 x 106 of these cells. In group II, each one received 0,2 ml of cross-linked hyaluronic acid gel containing the same amount of these cells. With three weeks of implantation, human cells and vessels were identified in both carriers. However, with eight weeks of implantation, only in hyaluronic acid gel human cells and vessels were present
 
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Publishing Date
2005-10-05
 
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