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Doctoral Thesis
DOI
https://doi.org/10.11606/T.42.2018.tde-31012018-170056
Document
Author
Full name
Caroline Mendes
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2017
Supervisor
Committee
Cipolla Neto, Jose (President)
Amaral, Fernanda Gaspar do
Carvalho, Carla Roberta de Oliveira
Gomes, Guilherme
Loureiro, Tatiana Carolina Alba
Title in Portuguese
Melatonina e termorregulação.
Keywords in Portuguese
Glândula pineal
Idosos
Melatonina
Termorregulação
Abstract in Portuguese
A melatonina desempenha funções fisiológicas importantes, como o aumento da capacidade de termogênese do tecido adiposo marrom. Além dos depósitos adiposos branco e marrom, há um terceiro tipo, as células adiposas beges. Presentes no tecido adiposo branco, apresentam características semelhantes aos adipócitos marrons via um processo denominado browning que está relacionado com a termogênese e aumento do gasto energético. Diante disso, o objetivo deste estudo foi investigar o papel da melatonina sobre a regulação da temperatura corporal em animais idosos obesos da linhagem Wistar que apresentam produção de melatonina prejudicada. Por 16 semanas os animais foram divididos nos grupos controle e suplementado com melatonina e viu-se que os adipócitos marrons e beges atuam de forma coordenada e complementar para garantir a produção de calor de maneira adequada e que a melatonina tem papel importante nos mecanismos termorregulatórios, assegurando maior capacidade de suportar ao frio e, ainda, participando da regulação do balanço energético.
Title in English
Melatonin and thermoregulation.
Keywords in English
Elderly
Melatonin
Pineal gland
Thermoregulation
Abstract in English
The hormone melatonin plays several physiological functions, one of them is the increase of thermogenesis capacity of brown adipose tissue. In addition to white and brown adipose deposits, there is also a third type, the beige adipocyte, which presents similar characteristics to brown adipocytes, induced in a process called browning. This process is related to thermogenesis and the increase of energy expenditure. Thus, the aim of this study was to investigate the role of melatonin on the regulation of body temperature in elderly obese animals that have impaired production of melatonin. Male-Wistar were divided into control group and group supplemented with melatonin, and the experimental protocol lasted 16 weeks. The main results showed that brown and beige adipocytes act in a coordinated and complementary way to ensure adequate heat production and that melatonin plays an important role in the thermoregulatory mechanisms, ensuring greater capacity to withstand the cold and, also, participating in the regulation of the energy balance.
 
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Publishing Date
2018-01-31
 
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