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Master's Dissertation
DOI
10.11606/D.42.2001.tde-30032001-121420
Document
Author
Full name
Renata Hydee Hasue
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2000
Supervisor
Committee
Lagnado, Sara Joyce Shammah (President)
Britto, Luiz Roberto Giorgetti de
Elias, Carol Fuzeti
Title in Portuguese
Origem da inervação dopaminérgica da divisão central da amígdala expandida e da concha do núcleo Acumbens no rato.
Keywords in Portuguese
amígdala expandida
área tegmental ventral
núcleo acumbens
núcleo dorsal da rafe
substância cinzenta periaquedutal
tirosina hidroxilase
Abstract in Portuguese
A amígdala expandida central (EAc) inclui os núcleos central da amígdala (CeA), intersticial lateral da estria terminal (BSTl), intersticial do ramo posterior da comissura anterior (IPAC) e amígdala expandida sublenticular (SLEA). A EAc e a concha do acumbens possuem densa inervação dopaminérgica, implicada em processos motivacionais, e cuja origem foi estudada com a técnica de dupla marcação celular, combinando-se imunofluorescência para o traçador retrógrado Fluoro-Gold e para a tirosina hidroxilase. Nossos resultados indicam que a inervação dopaminérgica do CeA e BSTl é semelhante, se originando em igual proporção da área tegmental ventral (A10) e do núcleo dorsal da rafe/substância cinzenta periaquedutal (A10dc). A inervação dopaminérgica da SLEA, IPAC e concha do acumbens se origina principalmente do grupo A10. Com um anticorpo específico para dopamina vimos que parte da projeção do A10dc para o CeA é de fato dopaminérgica. Os grupos dopaminérgicos diencefálicos não inervam a EAc e a concha do acumbens.
Title in English
Origin of dopaminergic fibers to the central extended amygdala and nucleus accumbens shell in the rat.
Keywords in English
dorsal raphe nucleus
extended amygdala
nucleus accumbens
periaqueductal gray
tyrosine hydroxilase
ventral tegmental area
Abstract in English
The central extended amygdala (EAc) includes the central amygdaloid nucleus (CeA), lateral bed nucleus of the stria terminalis (BSTl), interstitial nucleus of the posterior limb of the anterior commissure (IPAC) and sublenticular extended amygdala (SLEA). The dopaminergic innervation of the EAc and nucleus accumbens shell is functionally related to motivational processes. Its origin was studied by combining immunofluorescence to tyrosine hydroxylase and Fluoro-Gold, used as retrograde tracer. Our results show that dopaminergic fibers to the CeA and BSTl derive in equal proportion from neurons in ventral tegmental area (A10) and in dorsal raphe nucleus/periaqueductal gray (A10dc). Dopaminergic inputs to SLEA, IPAC and accumbens shell arise mainly from A10 neurons. Using a dopamine antibody, we confirmed that A10dc projections to CeA are in part dopaminergic. Futhermore, the present data indicate that the diencephalic dopaminergic groups do not project to EAc and accumbens shell.
 
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dissertacao.pdf (1.91 Mbytes)
Publishing Date
2005-04-04
 
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