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Master's Dissertation
DOI
https://doi.org/10.11606/D.42.2012.tde-29012013-103759
Document
Author
Full name
Caroline Mendes
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2012
Supervisor
Committee
Cipolla Neto, Jose (President)
Alaniz, Miriam Helena Fonseca
Silva, Cristina das Neves Borges
Title in Portuguese
Adaptações do animal idoso ao exercício: papel da suplementação diária com melatonina.
Keywords in Portuguese
Exercício físico
Glândula pineal
Idosos
Melatonina
Ratos
Abstract in Portuguese
A glândula pineal, via melatonina (MEL), desempenha uma importante função regulatória no metabolismo de carboidratos e parece ser de fundamental importância nas adaptações metabólicas dos tecidos adiposo e muscular. Evidências mostram que animais pinealectomizados são incapazes de se adaptarem a condições estressantes e não conseguem desenvolver as alterações adaptativas ao exercício. Sabendo que o animal idoso apresenta considerável redução da produção de MEL, o objetivo deste estudo foi investigar a adaptação metabólica ao treinamento físico no animal idoso com e sem reposição de MEL. Para tanto, foram utilizados ratos Wistars, com 12 meses de vida, que foram divididos em 4 grupos: controles sedentários; controles treinados; suplementados com MEL sedentários; suplementados com MEL treinados. A suplementação com MEL teve a duração de 16 semanas, enquanto o treinamento físico teve a duração de 8. Os resultados mostraram que a suplementação com MEL em animais idosos tem grande importância nas adaptações induzidas pelo treinamento físico aeróbio
Title in English
Adaptations of the elderly animal to exercise: role of daily supplementation with melatonin.
Keywords in English
Elderly
Melatonin
Mice
Physical activity
Pineal gland
Abstract in English
The pineal gland, melatonin (MEL), plays an important physiological and regulatory function in carbohydrate metabolism and seems to be of fundamental importance in determining the metabolic adaptations of adipose and muscle tissues. Evidence shows that pinealectomized animals are unable to adapt to stressful conditions, thus fail to develop adaptive metabolic changes to aerobic exercise and therefore do not exhibit the same performance as control trained animals. Knowing that the elderly animal presents a considerable reduction in MEL production, the objective of this study was to investigate the metabolic adaptation to exercise training in aged animals with and without replacement of MEL. The animals, Male-Wistar, were divided into four groups: sedentary control, trained control, sedentary treated with MEL, trained treated with MEL. The Supplementation with MEL lasted 16 weeks, while physical training lasted 8 weeks. The results demonstrated that MEL supplementation in elderly animals is of great importance in adaptations induced by aerobic exercise.
 
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Publishing Date
2013-03-15
 
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