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Doctoral Thesis
DOI
https://doi.org/10.11606/T.42.2017.tde-03102017-120456
Document
Author
Full name
Laís Oliveira Dellacqua
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2017
Supervisor
Committee
Antunes, Vagner Roberto (President)
Bittencourt, Jackson Cioni
D'Avila, Kátia de Angelis Lobo
Moreira, Thiago dos Santos
Oliveira, Edilamar Menezes de
Title in Portuguese
Benefícios cardiovasculares do treinamento físico aeróbio em ratos espontaneamente hipertensos em envelhecimento.
Keywords in Portuguese
envelhecimento
exercício físico e controle neural da circulação
Hipertensão
Abstract in Portuguese
Introdução: O quadro hipertensivo pode ser agravado quando associado ao envelhecimento, e a prática do exercício físico está relacionada a uma melhora do quadro hipertensivo. Métodos: Foram utilizados ratos SHR e WKY com 12 meses de idade, divididos em dois grupos: treinados (T) e sedentários (S). Resultados: O desempenho na esteira dos animais WKY e SHR treinados foi maior na quarta na oitava semana. Não houve diferença no peso corporal dos animais. A PAS, PAD e PAM dos animais SHR treinados por 2 e 8 semanas foi menor do que a encontrada nos animais sedentários de 8 semanas . O componente HF foi maior nos animais treinados por 8 semanas, em comparação aos grupos sedentários . O exercício físico não foi capaz de modificar a contagem de neurônios positivos para ChAT e TH, tanto nos animais SHR quanto nos animais WKY. Conclusão: O exercício físico foi capaz de melhorar o desempenho em esteira, diminuir a pressão arterial sistólica, diastólica e média, melhorar a sensibilidade barorreflexa e aumentar o componente HF para o coração.
Title in English
Cardiovascular benefits of aerobic exercise training in aging spontaneously hypertensive rats.
Keywords in English
Aging.Exercise training
Hypertension
Neural control of circulation
Abstract in English
Introduction: The hypertension can be aggravated when associated with aging, and the practice of physical exercise is related to an improvement of the hypertensive picture. Methods: Twelve-month-old SHR and WKY rats were divided into two groups: trained (T) and sedentary (S). Results: The performance of WKY and SHR trained animals was higher in the fourth and eighth week. There was no difference in the body weight of the animals. The SBP, DBP and MAP of SHR animals trained for 2 and 8 weeks was lower than that found in sedentary animals of 8 weeks. The HF component was higher in trained animals for 8 weeks compared to sedentary groups. Physical exercise was not able to modify the number of ChAT and TH positive neurons in both SHR and WKY animals. Conclusion: Physical exercise was able to improve treadmill performance, decrease systolic, diastolic and mean blood pressure, improve baroreflex sensitivity and increase the HF component to the heart.
 
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Publishing Date
2017-10-04
 
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