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Doctoral Thesis
DOI
https://doi.org/10.11606/T.42.2008.tde-24032009-133946
Document
Author
Full name
Soraya Ferreira Habr
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Camarini, Rosana (President)
Baldo, Marcus Vinicius Chrysostomo
Bernardi, Maria Martha
Planeta, Cleopatra da Silva
Torrão, Andréa da Silva
Title in Portuguese
Efeitos da administração de interleucina-2 na liberação in vivo de dopamina no nucleus accumbens e no comportamento maternal em ratas
Keywords in Portuguese
Comportamento de ataque animal
Comportamento materno animal
Interleucina-2
Microdiálise
Neurotransmissores
Rato
Abstract in Portuguese
A interleucina-2 (IL-2) atua na modulação da atividade dopaminérgica, que influencia o comportamento maternal. Neste estudo observou-se que o estado lactacional reduziu a atividade geral em campo aberto, porém não alterou os níveis de dopamina e seus metabólitos. A administração de IL-2, tanto sistêmica com diretamente no N.Ac não alterou a atividade geral em campo aberto, indicando a ausência de efeito motor da mesma. Além disso, a administração de IL-2 sistêmica e no N.Ac reduziu as porcentagens de ratas que agrupam os filhotes e de filhotes agrupados por rata. A injeção de IL-2 no N.Ac aumentou as latências de busca do primeiro e segundo filhotes e o comportamento agressivo. A administração sistêmica de IL-2 em ratas virgens reduziu somente do valor absoluto de DOPAC (metabólito de dopamina) após 100 e 120. Este achado corrobora a idéia de que o IL-2 altera a atividade dopaminérgica. Os resultados sugerem que a administração sistêmica da dose de IL-2 estudada não influencia de forma significativa os níveis de dopamina e de seus metabólitos no N.Ac.
Title in English
Effects of interleukin-2 administration on nucleus accumbens dopamine levels and maternal behavior in rats.
Keywords in English
An attack animal behavior
Interleukin-2
Microdialysis
Mothering animal
Mouse
Neurotransmitters
Abstract in English
Interleukin-2 (IL-2) modulates the dopaminergic neurotransmission, that into the nucleus accumbens (N.Ac) plays a role in maternal behavior. The IL-2 dose used in this study does not have motor effects. Both peripheral and central N.Ac injections decreased the percent of mothers grouping pups together and the number of grouped pups. IL-2 injections into the N.Ac resulted in longer latencies to retrieve first and second pups and increased aggressive behavior. In order to test if these behavioral effects would be related to the IL-2 reduced the DOPAC (dopamine metabolite) concentrations in the N.Ac of virgin rats treated with IL-2. This suggests suggest that the IL-2 dose used in this study does not alter so much the dopaminergic transmission by influencing extracellular levels of this neurotransmitter.
 
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Publishing Date
2009-03-30
 
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