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Doctoral Thesis
DOI
https://doi.org/10.11606/T.42.2010.tde-06082010-134631
Document
Author
Full name
Elaine Cristina Rodrigues da Costa
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Felicio, Luciano Freitas (President)
Cury, Yara
Freitas, Maria Isabel Roth de Carvalho
Souza, Carolina Demarchi Munhoz de
Taricano, Ingrid Dragan
Title in Portuguese
Aspectos neuroimunes de camundongos tratados com morfina.
Keywords in Portuguese
Alcalóides
Camundongos
Comportamento animal
Corticosterona
Macrófagos
Morfina
Neuroimunomodulação
Neuroquímica de animal
Tumor
Abstract in Portuguese
Injeções repetidas de psicoestimulantes e/ou compostos opióides desencadeiam respostas comportamentais, bioquímicas, endócrinas e celulares diferentes daquelas induzidas pela exposição aguda. Em particular, a morfina, considerada como o protótipo do estimulante opioidérgico, tem despertado grande interesse devido a seus efeitos múltiplos. Assim, no presente estudo avaliaram-se as consequências dos tratamentos agudo e repetido com morfina (20mg/kg) em camundongos sobre os seguintes aspectos: atividade geral; níveis séricos de corticosterona; concentrações corticais, estriatais e hipotalâmicas de noradrenalina, dopamina e serotonina, de seus metabólitos e as taxas de renovação destes neurotransmissores; atividade funcional ex vivo de neutrófilos sanguíneos e de macrófagos peritoneais, sendo estes desafios realizados in vivo com diferentes estímulos imunológicos, infecciosos ou não; crescimento tumoral e a sobrevida de camundongos portadores de um tumor ascítico de Ehrlich. Os resultados obtidos mostraram que os tratamentos agudo e repetido com morfina modulam diferentemente as repostas comportamental e neuroendócrina, dependendo do tempo de observação pós-desafio. Portanto, conclui-se que camundongos tratados repetidamente com morfina (20mg/kg) apresentam alterações comportamentais e neuroendócrinas que, no entanto, não foram acompanhadas por diferenças nas avaliações de atividade imune inata.
Title in English
Neuroimmune aspects of morphine-treated mice.
Keywords in English
Alkaloids
Animal behaviour
Corticosterone
Macrophages
Mice
Morphine
Neurochemistry of animal
Neuroimmunomodulation
Tumor
Abstract in English
Repeated administrations of psychostimulant and/or opioid compounds trigger different behavioral, biochemical, endocrine and cellular responses as compared with those induced by acute exposure. Morphine, has attracted great interest due to its multiple effects. Thus, this study evaluated the effects of acute and repeated treatment with morphine (20mg/kg) in mice on the following: locomotor activity; serum levels of corticosterone; cortical, striatal and hypothalamic concentration of dopamine, noradrenaline and serotonin, as well as their metabolites and turnover; blood neutrophils and peritoneal macrophage activity ex vivo, which were challenged with different immunological stimulants; tumor growth and survival of mice with Erlich ascitic tumor. The results showed that acute and repeated morphine treatment differently modulated behavioral and neuroendocrine responses, depending on the these period after the injection challenge. Thus, it is concluded that mice repeatedly treated with morphine (20mg/kg) present behavioral and neuroendocrine changes; however, this changes were not accompanied by variation in innate immune activity.
 
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Publishing Date
2010-09-13
 
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