Estudo dos efeitos dos psicofármacos acamprosato e levomepromazina sobre as formas epimastigotas e tripomastigotas do Trypanosoma cruzi in vitro.

Lange, Inga Eva Stik

doi:10.11606/D.42.2012.tde-21092012-083842

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Master's Dissertation

DOI

https://doi.org/10.11606/D.42.2012.tde-21092012-083842

Document

Master's Dissertation

Author

Lange, Inga Eva Stik (Catálogo USP)

Full name

Inga Eva Stik Lange

Institute/School/College

Instituto de Ciências Biomédicas

Knowledge Area

Biology of Host-Pathogen Interactions

Date of Defense

2012-06-25

Published

São Paulo, 2012

Supervisor

Silber, Ariel Mariano (Catálogo USP)

Committee

Silber, Ariel Mariano (President)
Marinho, Claudio Romero Farias
Takahashi, Anita Hilda Straus

Title in Portuguese

Estudo dos efeitos dos psicofármacos acamprosato e levomepromazina sobre as formas epimastigotas e tripomastigotas do Trypanosoma cruzi in vitro.

Keywords in Portuguese

Trypanosoma cruzi
Acamprosato
Epimastigotas
Fármacos psicotrópicos
Gaba
Metabolismo
Tripomastigotas

Abstract in Portuguese

Nosso laboratório vem trabalhando no metabolismo de GABA, projeto derivado de estudos da via prolinaglutamato em T. cruzi. Os efeitos dos psicofarmacos, acamprosato e levomepromazina, em diferentes aspectos da biologia do T. cruzi apontam estes como compostos líderes para o desenho de novas drogas com capacidade terapêutica otimizada contra o T. cruzi.

Title in English

Study of the effects of acamprosate and levomepromazine psycodrugs in epimastigotes and tripomastigotes forms of Trypanosoma cruzi in vitro.

Keywords in English

Trypanosoma cruzi
Acamprosate
Epimastigotes
Gaba
Metabolism
Psychotropic drugs
Trypomastigotes

Abstract in English

Our laboratory has been working on the metabolism of the GABA in T. cruzi, a project derived from studies on the prolineglutamate pathway in this organism. The effects of two psycodrugs, acamprosate and levomepromazine, showed that both could be leader compounds for the new drugs design with optimized therapeutic capacity against T.cruzi.

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Publishing Date

2012-10-25

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