• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Doctoral Thesis
DOI
https://doi.org/10.11606/T.42.2013.tde-26062014-141424
Document
Author
Full name
Sheila Alexandra Belini Nishiyama
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2013
Supervisor
Committee
Campos, Mario Julio Avila (President)
Cirelli, Joni Augusto
Elias Junior, Waldir Pereira
Groppo, Francisco Carlos
Nunes, Fabio Daumas
Title in Portuguese
Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico.
Keywords in Portuguese
Citocinas
Doenças nutricionais e metabólicas
Doenças periodontais
Inflamação
Obesidade
Periodonto
Abstract in Portuguese
O presente trabalho teve por objetivo avaliar a microbiota subgingival pela técnica de Checkerboard e o perfil de citocinas por imunoensaio com princípio sanduíche baseado na tecnologia fluxometria do fluido gengival e soro em indivíduos não obesos; e em indivíduos com obesidade, antes e após cirurgia bariátrica. Diferenças na microbiota bucal foram observadas entre não obesos e obesos para 19 espécies bacterianas, particularmente E. corrodens que apresentou diferenças significativas em obesos, com consequente redução após a perda de peso. As citocinas IL-1b, IL-6, IL-10, IL-13, IL-17, TNF-a, leptina e adiponectina apresentaram diferenças estatisticamente significantes (p<0,05) quando esses indivíduos foram comparados. Todas as citocinas analisadas no soro diminuíram após a redução de peso, apenas a adiponectina apresentou concentrações significativamente mais elevadas (p<0,05). Assim, a obesidade promove alterações na microbiota subgengival e na resposta imunológica local e sua prevenção ou controle pode favorecer a saúde bucal.
Title in English
Potential impact of bariatric surgery on periodontal health in obese subjects. Determining the microbiological and immunological profile.
Keywords in English
Cytokines
Inflammation
Nutritional and metabolic diseases
Obesity
Periodontal diseases
Periodontium
Abstract in English
In this study, the aimed to evaluate the subgingival microbiota using Checkerboard technique and the cytokines profile by using immunoassay based on the flowmetry gingival fluid and serum in non-obese and obese individuals, before and after bariatric surgery. Differences were observed in the oral microbiota between nonobese and obese for 19 bacterial species, particularly E. corrodens that showed significant differences in obese, with a consequent reduction after weight loss. The cytokines IL-1b, IL-6, IL-10, IL-13, IL-17, TNF-a, leptin and adiponectin were statistically different (p <0.05) when these individuals were compared. All analyzed cytokines in serum decreased after weight reduction only adiponectin concentrations showed significantly higher (p <0.05). Thus, obesity causes changes in the subgingival microbiota and the local immune response, and prevention and control can promote oral health.
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
Publishing Date
2014-06-28
 
WARNING: The material described below relates to works resulting from this thesis or dissertation. The contents of these works are the author's responsibility.
  • NISHIYAMA, SAB, et al. Occurrence of herpes simplex virus 1 and three periodontal bacteria in patients with chronic periodontitis and necrotic pulp. Canadian Journal of Microbiology , 2008, vol. 54, p. 326-330.
  • NISHIYAMA, Sheila A B, et al. Detection of putative periodontal pathogens in subgingival specimens of dogs. Brazilian Journal of Microbiology, 2007, vol. 38, p. 23-28.
  • NISHIYAMA, SAB, TOMAZINHO, Luiz Fernando, e AVILA-CAMPOS, M. J. Participação das espéices relacionadas ao complexo vermelho nas infecções de origem endodôntica. In 21 Reunião Anual da SBPqO, Águas de Lindóia, 2004. 21 Reunião Anual SBPqO., 2004. Resumo.
  • NISHIYAMA, Sheila A B, SENHORINHO, Gerusa N A, e AVILA-CAMPOS, M. J. Presença de periodontopatógenos em cães com periodontites. In XXIII Congresso Brasileiro de Microbiologia, Santos, 2005. XXIII Congresso Brasileiro de Microbiologia., 2005. Resumo.
  • NISHIYAMA, Sheila A B, TOMAZINHO, Luiz F, e AVILA-CAMPOS, M. J. Detecção por nested-PCR do virus herpes simples em bolsa periodontal, em tecido pulpar necrótico e sulco gengival sadio. In XXIII Congresso Brasileiro de Microbiologia, Santos, 2005. XXIII Congresso Brasileiro de Microbiologia., 2005. Resumo.
All rights of the thesis/dissertation are from the authors
CeTI-SC/STI
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2024. All rights reserved.