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Master's Dissertation
DOI
https://doi.org/10.11606/D.42.2010.tde-27092010-105116
Document
Author
Full name
André Valerio da Silva
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Bittencourt, Jackson Cioni (President)
Antunes, Vagner Roberto
Horta Junior, José de Anchieta de Castro e
Title in Portuguese
Estudo das projeções hipotalâmicas para a região urocortinérgica do complexo oculomotor.
Keywords in Portuguese
Fluoro-gold
Amina-Dextrana-Biotinilada
Estereotaxia
Hipotálamo (Estudo)
Núcleo de Edinger-Westphal
Urocortina-1
Abstract in Portuguese
O neuropeptídeo urocortina 1 (UCN 1) tem entre os seus principais locais de expressão o núcleo de Edinger-Westphal (EW) e o núcleo lateral superior da oliva. Após sua descoberta, sugeriu-se que o EW e o núcleo paraventricular do hipotálamo (PVH) possuíssem papéis complementares e opostos na resposta ao estresse, porém, não existem trabalhos que relacionam anatomicamente núcleos hipotalâmicos e o EW. A fim de contribuir para esta área foi proposto o mapeamento das aferências hipotalâmicas do EW, através da injeção de Fluoro-Gold neste núcleo e posterior mapeamento de suas aferências. Os resultados encontrados foram: PVH, área hipotalâmica lateral (LHA) e o núcleo posterior do hipotálamo (PH) e outras regiões do sistema nervoso central. Para controle, o traçador anterógrado Amina Dextrana Biotinilada, foi injetado nos núcleos/áreas hipotalâmicas PVH, LHA e PH sendo encontradas fibras próximas as células urocortinérgicas do EW. Nossos dados mostram um possível envolvimento das células UCN 1 do EW com o controle de funções autonômicas e neuroendócrinas.
Title in English
Study of the hypothalamic projections to the urocortinergic cells in the oculomotor complex.
Keywords in English
Fluoro-gold
Dextran-Amine-Biotin
Edinger-Westphal nucleus
Hypothalamus (Study)
Stereotaxic
Urocortin-1
Abstract in English
The neuropeptide urocortin 1 (UCN 1) has its main sites of expression at the Edinger-Westphal nucleus (EW) and the lateral superior olivary nucleus. After its discovery has suggested that EW and paraventricular nucleus of hypothalamus (PVH) have complementary and opposing roles in the stress response. However, there are no works relating anatomically the hypothalamic nuclei and EW. To contribute to this area we proposed mapping the hypothalamic afferents of the EW. We have used the Fluoro-Gold injected in the EW as a result of we have found retrogradely labeled cells in the following nuclei: PVH, lateral hypothalamic area (LHA), posterior hypothalamic nucleus (PH) and other regions of the central nervous system. For control, the anterograde tracer biotinylated dextran amine was injected into the nuclei/areas hypothalamic PVH, LHA, and PH we have found anterogradely labeled fibers in a very close apposition over urocortinergic cells at EW. Based on these data we are suggesting a involvement of cells with UCN 1 EW control of autonomic and neuroendocrine functions.
 
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Publishing Date
2010-10-20
 
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