• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Master's Dissertation
DOI
10.11606/D.42.2013.tde-13032014-162752
Document
Author
Full name
Caroline Antunes Lino
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2013
Supervisor
Committee
Chaves, Maria Luiza Morais Barreto de (President)
Ferreira, Julio Cesar Batista
Gomes, Marcelo Damario
Title in Portuguese
O sistema ubiquitina-proteassoma no modelo de hipertrofia cardíaca induzida por hormônio tireoidiano.
Keywords in Portuguese
Glândula tireóide
Hipertireoidismo
Hormônios tireoidianos
Metabolismo de proteína
Proteassoma
Sistema ubiquitina proteassoma
Abstract in Portuguese
Disfunções da glândula tireóide são, frequentemente, associadas a manifestações cardiovasculares e, em situações de hipertireoidismo, o coração hipertrofia. A hipertrofia cardíaca (HC) consiste em uma resposta adaptativa caracterizada pelo aumento de síntese de proteínas estruturais. O Sistema Ubiquitina Proteassoma (UPS) corresponde ao principal mecanismo de proteólise intracelular e crescentes evidências sugerem seu envolvimento no desenvolvimento da HC. O objetivo do presente estudo foi avaliar a modulação do UPS no tecido cardíaco de animais submetidos ao hipertireoidismo. Os resultados referentes ao aumento da atividade e expressão do proteassoma (PT) cardíaco apresenta-se mais contundente no grupo tratado por 7 dias, período em que a HC já encontra-se estável. Ao término de 14 e 21 dias, a modulação desse sistema tende à normalização. Os resultados obtidos atestam evidências da literatura que sugerem o aumento da atividade do PT cardíaco como resposta compensatória ao aumento de síntese proteica.
Title in English
The ubiquitin proteasome system in thyroid hormone-induced cardiac hypertrophy model.
Keywords in English
Hyperthyroidism
Proteasome
Protein metabolism
Thyroid gland
Thyroid hormones
Ubiquitin proteasome system
Abstract in English
Thyroid gland disorders are often associated with cardiovascular events and hyperthyroidism state promotes cardiac hypertrophy (CH). CH consists in adaptive response characterized by increased synthesis of structural proteins. The Ubiquitin Proteasome System (UPS) is the major mechanism of intracellular proteolysis and increased evidences suggest its involvement in the development of CH. The aim of this study was to evaluate the modulation of UPS in cardiac tissue of animals subjected to hyperthyroidism. The results related to the increased proteasome (PT) activity and expression in the heart was more accentuated in the group treated for 7 days, when the CH process finds stable. At the end of 14 and 21 days of hyperthyroidism, the modulation of cardiac UPS achieves standard values. These results suggest an increased activity of cardiac PT as a compensatory response to protein synthesis induced by thyroid hormones.
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
Release Date
2018-03-20
Publishing Date
2014-03-29
 
All rights of the thesis/dissertation are from the authors
Centro de Informática de São Carlos
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2019. All rights reserved.