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Master's Dissertation
DOI
https://doi.org/10.11606/D.42.2008.tde-13032009-102250
Document
Author
Full name
Paulo Alexandre Galvanini
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Liberti, Edson Aparecido (President)
Gomes, Odair Alfredo
Maifrino, Laura Beatriz Mesiano
Title in Portuguese
Efeitos da lesão térmica corporal na mucosa e nos componentes do plexo mioentérico do estômago de ratos.
Keywords in Portuguese
Estômago
Mucosa gástrica
Plexo mioentérico
Queimadura
Sistema nervoso entérico
Abstract in Portuguese
O Sistema nervoso entérico está localizados entre as camadas constituintes das paredes do trato gastrintestinal, entre as camadas musculares longitudinal e circular, que se estende por todo o trato digestório, desde o esôfago até o reto. Desordens gastrintestinais são complicações comuns causadas pela lesão térmica. A presente pesquisa avalia, em estômagos de ratos alterações na mucosa e no plexo mioentérico submetidos à lesão térmica corporal. O número de neurônios NADH-d e NADPH-d aumentaram significativamente nos animais queimados. Analisando a média da área do perfil dos neurônios NADH-dr e NADPH-dr evidenciaram uma diminuição significativa de 26% e 24%, respectivamente, na área do perfil dos neurônios dos animais queimados. Assim, associados o VIP o NO e a acetilcolina se apresentaram de maneira a interferir no esvaziamento gástrico causando ulcerações que foram observadas pela técnica da MEV na mucosa gástrica. Com esses dados, pode-se concluir que a LTC interfere no plexo mioentérico do estômago de ratos causando uma gastroparesia.
Title in English
Effects of burn injury in mucous and stomach myenteric plexus structure of rats.
Keywords in English
Burning
Enteric nervous system
Gastric mucosa
Myenteric plexus
Stomach
Abstract in English
The enteric nervous system is located among the layer constituents of the gastrintestinal tract. Between the longitudinal and circular muscle layers, which extend throughout the digestory tract from the esophagus to the rectum. Gastrintestinal disorders are common complications caused by burn injury. This research evaluates, in stomach of rats changes in the mucosal and myenteric plexus, subjected burn injury. The number of neurons NADH-d and NADPH-d significantly increased in burned animals. Analyzing the average area of the profile of the neurons NADH-dr and NADPH-dr, showed a significant decrease of 26% and 24%, respectively, in the area of the profile of the neurons of the burned animals. Thus, the association of VIP, NO and acetylcholine is presented so as to interfere with gastric emptying causing changes in the mucosal wich were observed by the technique of MEV. With this data, it can be conclude that the burn injury interferes in the myenteric plexus of the stomach of rats causing a gastroparesis.
 
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Publishing Date
2009-03-23
 
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