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Master's Dissertation
DOI
10.11606/D.42.2016.tde-09082016-103424
Document
Author
Full name
Rodrigo de Andrade Rufino
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2016
Supervisor
Committee
Canteras, Newton Sabino (President)
Munhoz, Carolina Demarchi
Oliveira, Maria Gabriela Menezes de
Title in Portuguese
Investigação da substância cinzenta periaquedutal (PAG) na organização das respostas de defesa frente ao predador.
Keywords in Portuguese
Avaliação de risco
Comportamento de defesa
Núcleo hipotalâmico anterior
Septo lateral
Substância cinzenta periaquedutal
Abstract in Portuguese
Primeiramente, investigamos as respostas defensivas de animais lesionados da parte dorsal da PAG rostral durante o confronto predatório. Estes animais permaneciam com as respostas de avaliação de risco (AR) porem perdem as respostas de freezing. Em um segundo estudo, analisamos as respostas defensivas frente ao predador em animais lesionados da parte ventrolateral da PAG caudal. Estes animais perdem as respostas de freezing e aumentam as respostas de AR. Será que as respostas de AR dependem da integridade da parte dorsal rostral e ventrolateral caudal da PAG ? Por último, investigamos as respostas defensivas em animais com lesão combinada destas áreas. Observamos uma diminuição drástica das AR e um aumento das respostas exploratórias. Provavelmente, as respostas de AR estão sendo moduladas pela parte dorsal rostral e ventrolateral caudal da PAG através de seus alvos ascendentes hipotalâmicos, e estes com o septo lateral. As respostas de freezing parecem ser moduladas por projeções descendentes da PAG para a medula espinal.
Title in English
Investigation of periaqueductal gray (PAG) in the organization of the defense responses front predator.
Keywords in English
Anterior hypothalamic nucleus
Defensive behavior
Periaqueductal gray
Risk assessment
Septum lateral
Abstract in English
First, we investigated the defensive responses of injured animals of the dorsal part of the rostral PAG during predatory confrontation. These animals remained with the risk assessment responses (AR) however lose the freezing of response. In a second study, we analyzed the defensive responses front predator injured animals in the ventrolateral part of the caudal PAG. These animals lose the responses of freezing and increase AR responses. Does the AR responses depend on the integrity of dorsal part rostral and caudal ventrolateral PAG? Finally, we investigated the defensive responses in animals with combined injury of these areas. We observed a dramatic decrease of AR and an increase in exploratory response. Probably AR responses are modulated by the dorsal part of the rostral and caudal ventrolateral PAG through its hypothalamic ascendant targets, and these with the lateral septum. Freezing responses appear to be modulated by descending projections from the PAG to the spinal cord.
 
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Release Date
2018-08-09
Publishing Date
2016-08-09
 
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