Desenvolvimento de programas computacionais visando a estimativa de parâmetros de interesse genético-populacional e o teste de hipóteses genéticas

Santos, Fernando Azenha Bautzer

doi:10.11606/D.41.2006.tde-02122006-121406

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Master's Dissertation

DOI

https://doi.org/10.11606/D.41.2006.tde-02122006-121406

Document

Master's Dissertation

Author

Santos, Fernando Azenha Bautzer (Catálogo USP)

Full name

Fernando Azenha Bautzer Santos

Institute/School/College

Instituto de Biociências

Knowledge Area

Biology (Genetics)

Date of Defense

2006-11-22

Published

São Paulo, 2006

Supervisor

Otto, Paulo Alberto (Catálogo USP)

Committee

Otto, Paulo Alberto (President)
Klaczko, Louis Bernard
Krieger, Henrique

Title in Portuguese

Desenvolvimento de programas computacionais visando a estimativa de parâmetros de interesse genético-populacional e o teste de hipóteses genéticas

Keywords in Portuguese

Equilíbrio de Hardy- Weinberg
Simulações computacionais
Testes exatos Jackknife

Abstract in Portuguese

A dissertação apresenta os resultados obtidos com o desenvolvimento de um programa de computação abrangente em interface gráfica para ambiente Windows visando a estimativa de parâmetros de interesse genético-populacional (freqüências alélicas, respectivos erros-padrão e intervalos de confiança a 95%) e o teste de hipóteses genéticas (equilíbrio de Hardy-Weinberg e análise de estruturação hierárquica populacional), por meio de métodos tradicionais e por meio de testes exatos obtidos com procedimentos de simulação (bootstrap e jackknife).

Title in English

Development of scientific software with the aim of estimating parameters of population genetic interest and the testing genetic hypotheses

Keywords in English

Allele frequencies
Computer simulation procedures (bootstrap and jackknife)
Exact confidence intervals
Hardy-Weinberg population ratios

Abstract in English

The dissertation presents the results obtained with the development of a comprehensive computation program (software), running on the Windows (MS) graphic interface, with the aim of: (a) estimating parameters of population genetic interest (such as allelic frequencies and their corresponding standard errors and 95% confidence intervals); and (b) performing the testing of genetic hypotheses (Hardy-Weinberg population ratios and analysis of population hierarchical structure) by means of traditional methods as well as through exact tests obtained with computer simulation procedures (bootstrap and jackknife methods).

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Publishing Date

2007-02-09

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