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Doctoral Thesis
DOI
10.11606/T.25.2017.tde-03042017-174435
Document
Author
Full name
Larissa Pinceli Chaves
Institute/School/College
Knowledge Area
Date of Defense
Published
Bauru, 2016
Supervisor
Committee
Wang, Linda (President)
Honório, Heitor Marques
Nahsan, Flávia Pardo Salata
Naufel, Fabiana Scarparo
Scaffa, Polliana Mendes Cándia
Title in Portuguese
Efeito de inibidores da atividade proteolítica na resistência de união de pino de fibra de vidro à dentina radicular após 12 meses
Keywords in Portuguese
Adesividade
Cimentos de resina
Inibidores enzimáticos
Pinos dentários
Abstract in Portuguese
O estabelecimento de uma camada híbrida adequada no canal radicular representa um dos principais desafios clínicos devido à dificuldade de acesso. Dessa forma, o uso de inibidores proteolíticos poderia tornar-se um recurso favorável. O objetivo deste estudo foi avaliar o efeito de inibidores proteolíticos na união de pino de fibra de vidro fixado com cimento adesivo, considerando os terços radiculares e tempos distintos, por meio da resistência de união (RU). Cento e quarenta e quatro raízes bovinas foram selecionadas e divididas em 6 grupos de tratamento, e redivididas em 3 subgrupos de acordo com os tempos de avaliação de 24 horas, 6 e 12 meses (n=8). Após o tratamento endodôntico e desobturação padronizados, as raízes foram cimentadas com pinos de fibra de vidro cônicos (Exacto/Angelus). As raízes foram tratadas com sistema adesivo convencional de três passos, Adper Scotchbond Multipurpose/ 3M ESPE (SBMP) e cimento dual RelyX ARC/ 3M ESPE. Após prévia divisão, foram alocadas em grupos CN (Controle Negativo- sem pré tratamento associado), CP (Controle Positivo- com agentes ativador e catalisador), EDTA (ácido etilenodiamino tetra-acético a 17%), CHX (digluconato de clorexidina a 2%), E-5 (E- 64 a 5 M) e E-10 (E-64 a 10 M). Após 24 horas, as raízes foram seccionadas perpendicularmente ao longo eixo e identificadas quanto à região, obtendo-se fatias de 1 mm de espessura (cervical, médio e apical), que foram armazenadas em saliva artificial para serem testadas. Todas as fatias foram submetidas ao teste de extrusão (push-out) na máquina de teste universal (Instron) com célula de carga de 50 N a 0,5 mm/min. Os dados foram analisados pelo teste de ANOVA a três critérios e comparações múltiplas com Tukey, ambos com p<0,05. Após 24 horas, não se observou diferenças entre os tratamentos. Após 6 meses, a CHX demonstrou melhor desempenho, cujo efeito não se prorrogou até os 12 meses. O uso de inibidores proteolíticos não foram capazes de preservar a resistência de união dos pinos intrarradiculares até o tempo de 12 meses.
Title in English
Effect of proteolytic activity inhibitors on bond strength of glass-fiber post to radicular dentin up to 12 months
Keywords in English
Adhesiveness
Dental Pins
Enzyme Inhibitors
Resin Cements
Abstract in English
The adequate establishment of hybrid layer in the root canal on bonding process is still a clinical challenge due to its hard access. Thus, the use of proteolytic inhibitors could become a favorable tool. The aim of this study was to evaluate the effect of proteolytic inhibitors in the bonding of a glass- fiber post fixed with a luting cement, regarding the root thirds and different times through the bond strength. One hundred and forty four bovine roots were selected and divided into 6 treatment groups, and subdivided according to the time of evaluation of 24 hours, 6 and 12 months (n=8). After endodontic treatment and standardized removal procedure, the roots were cemented with tapered glass fiber posts (Exacto/ Angelus). The roots were treated with three-step etch-and-rinse adhesive system Adper Scotchbond Multipurpose/ 3M ESPE (SBMP) and dual cement RelyX ARC/ 3M ESPE. After previous division, CN (negative- control without pre associated treatment), CP (Control positive- with activator and catalyst agents) EDTA (17% ethylenediaminetetraacetic acid) CHX (2% chlorhexidine digluconate) E-5 (5M E-64) and E-10 (10M E-64). After 24h, the roots were sectioned perpendicular to the long axis and identified according to third in 1mm thick slices (cervical, middle and apical), which were stored in artificial saliva to be tested. All slices were subjected to extrusion tests (push-out) in the universal test machine (Instron) at 50 N load cell at 0.5 mm/min. Data were analyzed with three-way ANOVA and multiple comparisons with Tukey test, both with p <0.05. After 24 hours, no differences were observed between treatments. After 6 months, CHX showed better performance, which did not last up 12 months. The proteolytic inhibitors performed differently in the bonding process over time; only CHX promoted inhibition at 6 months. The use of proteolytic inhibitors were not able to maintain the bond strength of intraradicular posts up time of 12 months.
 
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Publishing Date
2017-04-05
 
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