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Master's Dissertation
DOI
10.11606/D.23.2018.tde-12062018-101318
Document
Author
Full name
Nayara Fernanda Pereira
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2017
Supervisor
Committee
Biazevic, Maria Gabriela Haye (President)
Antunes, Jose Leopoldo Ferreira
Moysés, Simone Tetu
Nunes, Fabio Daumas
Title in Portuguese
Associação entre higiene oral e os cânceres de cabeça e pescoço
Keywords in Portuguese
Câncer
Fatores de risco
Higiene bucal
Abstract in Portuguese
Introdução: Com as demonstrações da relação entre inflamação, desregulação microbiológica e câncer, a higiene oral precária pode ser um fator risco. Objetivo: Verificar se a condição de higiene está associada com a ocorrência dos cânceres de cabeça e pescoço. Material e método: Foram analisadas variáveis de condição de higiene bucal, como frequência de escovação, dentes perdidos, necessidade e uso de prótese e visita regular ao dentista num estudo caso-controle, com pacientes de cinco hospitais do estado de São Paulo, pareados por sexo e idade, do projeto multicêntrico ,,Genoma do Câncer de Cabeça e Pescoço" (GENCAPO). Resultados: As neoplasias malignas mais frequentes foram as de bordo de língua (11,41%) e base de língua (10,92%). A análise estatística bivariada encontrou valores de Odds ratio abaixo de 1 para as variáveis: ,,escova 1x" (OR=0,33; IC0,25-0,44), ,,escova 2x" (OR=0,42;IC0,35-0,52), ,,usa fio sempre" (OR=0,19;IC0,13-0,27), ,,usa fio às vezes" (OR=0,19;IC0,15-0,24), ,,dentista todo ano" (OR=0,29;IC0,22-0,37), ,,higiene boa" (OR=0,21;IC0,166-0,27) e ,,higiene regular" (OR=0,19;IC0,16-0,25) e acima de 1 para ,,sangra sempre" (OR=2,40;IC1,40-4,09), ,,usa total" (OR=1,99;IC1,54-2,56), ,,6 ou mais dentes perdidos" (OR=3,30;IC2,67-4,08). A regressão logística multivariada encontrou significância para ,,escovar os dentes pelo menos 2x ao dia" (OR=0,53;IC0,37-0,75), ,,fio sempre" (OR=0,16;IC0,80-0,33) e para variável ,,6 ou mais dentes perdidos" (OR=3,86;IC2,67-5,57). Discussão: Os dados mostram a necessidade de cuidados orais e indicam que higiene precária pode ser um fator de risco. Conclusão: Bons hábitos de higiene bucal possuem relação inversa com ocorrência de câncer em cabeça e pescoço e esses pacientes tem mais comorbidades bucais.
Title in English
Association between oral hygiene and head and neck cancer
Keywords in English
Cancer
Oral hygiene
Risk Factors
Abstract in English
Introduction: As demonstrations of the relationship between inflammation, microbiological dysregulation and cancer, poor oral hygiene can be adapted for cancers. Objective: To verify if the hygiene condition is associated with the occurrence of head and neck cancers. Material and method: The variables of oral hygiene condition, such as toothbrushing frequency, missing teeth, need and use of prosthesis and regular visit to the dentist in a case-control study were analyzed with patients from five hospitals in the state of São Paulo, paired by sex and age, of the multicenter project ,,Genoma do Câncer de Cabeça e Pescoço" (GENCAPO). Results: The most frequent malignancies were those of the tongue border (11.41%) and tongue base (10.92%). The bivariate statistical analysis found odds ratio values below 1 for the variables' 1x brush '(OR = 0.33; IC0.253-0.44),' 2x brush '(OR = 0.42; IC0.34-0.52),' floss (OR = 0.19, IC0.13-0.27), 'sometimes uses floss' (OR = 0.19, IC0.15-0.24), 'dentist every year' (OR = 0.29, IC0.22-0.37), (OR = 0.21, IC0.167-0.27) and 'regular hygiene' (OR = 0.19, IC0.156-0.25) and above 1 for 'always bleeds' (OR = 2.40, CI 1.40-4.09), 'total use' (OR = 1,99, IC1,54-2,56), '6 or more missing teeth' (OR = 3,30, IC2,67-4,08). Multivariate logistic regression found significance for 'brushing the teeth at least 2x a day' (OR = 0.53, IC0.37-0.75), 'always wire' (OR = 0.16, IC0.80-0.32) and for variable '6 or more lost teeth '(OR = 3.86, IC2.67-5.57). Discussion: Data show the need for oral care and indicate that poor hygiene may be a risk factor. Conclusion: Good habits of oral hygiene have an inverse relation with the occurrence of head and neck cancer and these patients have more oral comorbidities.
 
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Publishing Date
2018-07-16
 
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