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Doctoral Thesis
DOI
https://doi.org/10.11606/T.23.2009.tde-28092009-153618
Document
Author
Full name
Luiz Alberto Dib Canonico
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2009
Supervisor
Committee
Romito, Giuseppe Alexandre (President)
Campos, Luciana Saraiva de
Freitas, Nívea Maria de
Lotufo, Mônica Andrade
Soares, Mario Sergio
Title in Portuguese
Detecção de periodontopatógenos do complexo vermelho em ateromas de artérias coronárias de pacientes com doença cardiovascular e periodontite crônica
Keywords in Portuguese
Aterosclerose
Doença Cardiovascular
Doença Periodontal
PCR
Periodontopatógenos
Abstract in Portuguese
Existe a hipótese, dentro da medicina periodontal, de uma possível relação entre doença periodontal e doenças cardíacas. Talvez a doença periodontal possa agir como um fator desencadeante para o desenvolvimento da doença cardiovascular. Vinte e oito pacientes portadores de aterosclerose e periodontite crônica, submetidos à intervenção cirúrgica de revascularização cardíaca e endarterectomia coronariana, participaram do estudo, cujo objetivo foi avaliar nas placas de ateroma de artérias coronárias a presença dos periodontopatógenos do complexo vermelho: Porphyromonas gingivalis, Tannerella forsythia e Treponema denticola. O DNA genômico foi extraídos das amostras de ateromas e se constatou a presença das bactérias através da reação em cadeia da polimerase (PCR). Detectou-se nas 28 amostras de ateroma: P. gingivalis em 50%, T. forsythia em 7,1% e T. denticola em 3,6% respectivamente. Estes resultados ajudam a defender a hipótese de que a doença periodontal pode ser um dos muitos fatores envolvidos com o desenvolvimento da doença cardiovascular, sendo mais um motivo para ser precocemente diagnosticada, prevenida e tratada.
Title in English
Deteccion of periodontopathogens of the red complex in the atheroma of the coronary arteries from patients with cardiovascular disease and chronic periodontitis
Keywords in English
Atherosclerosis
Cardiovascular Disease
PCR
Periodontal Disease
Periodontopathogens
Abstract in English
In the field of periodontal medicine there is the hypothesis of a possible connection between periodontal diseases and heart diseases. Maybe the periodontal disease may work as a triggering factor in the development of periodontal of cardiovascular diseases. Twenty-eight patients of atherosclerosis and cronical periodontitis patients were subjected to surgical intervention for cardiac revascularization and coronary endarterectomy, have made part of the study, whose objective was to evaluate the presence of periodontopathogens of the red complex in the atheroma platelets: Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola. Genomic DNA was extracted from atheroma samples, and the presence of bacteria was stated through polymerase chain reaction (PCR). In the 28 samples of atheroma were detected: P. gingivalis at 50%, T. forsythia at 7.1% and T. denticola at 3.6% respectively. These results help to sponsor the hypothesis that the periodontal disease can be one of several factors involved in the development of cardiovascular disease, being this another reason for its early diagnosis, prevention and treatment.
 
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Publishing Date
2009-12-21
 
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