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Master's Dissertation
DOI
https://doi.org/10.11606/D.23.2010.tde-03072010-101044
Document
Author
Full name
Juliana Noguti
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Mantesso, Andrea (President)
Deboni, Maria Cristina Zindel
Ribeiro, Daniel Araki
Title in Portuguese
Estudo do efeito do ozônio diluído em água na reparação óssea através de avaliação imunoistoquímica
Keywords in Portuguese
Ozônio
Proteínas da matriz óssea
Reparação óssea
Abstract in Portuguese
A aplicação de ozônio pode ser usada como uma alternativa no tratamento de inúmeras patologias. O objetivo é interferir positivamente na reparação tecidual e na anti-sepsia de injúrias, uma vez que o ozônio é um potente agente antimicrobiano e possui a capacidade de estimular a circulação sanguínea e a resposta imunomodulatória. Tais características justificam o interesse da sua aplicação na Medicina e na Odontologia. Quando em contato com fluidos orgânicos, o ozônio age como um oxidante gerando a formação de moléculas reativas do oxigênio e produtos de lipídeos oxidantes que influenciam em eventos bioquímicos do metabolismo celular. A proposição deste estudo foi avaliar a aplicação do ozônio diluído em água no processo de reparação óssea através de análise morfológica e imunoistoquimica em modelo animal. Nossos resultados mostraram que a irrigação da ferida cirúrgica com ozônio diluído em água ocasionou atraso na reparação e que este era mais exuberante no início do processo.
Title in English
Study of the effect of ozone dissolved in water in the bone repair by immunohistochemical evaluation
Keywords in English
Bone matrix proteins
Bone repair
Ozone
Abstract in English
The ozone therapy can be used as an alternative for the treatment of numerous diseases. The goal is to positively affect tissue repair and antisepsis as ozone is a potent antimicrobial agent and has the ability to stimulate blood circulation and immunomodulatory response. These characteristics justify the interest of its application in Medicine and Dentistry. When in contact with body fluids, ozone acts as an oxidant generating reactive oxygen molecules and oxidative products of lipids influencing biochemical events of cellular metabolism. Therefore, the purpose of this study was to evaluate, in an animal model, the effect of ozone application during the bone wound healing process. These analyses were performed by the study of bone cells morphology and immunohistochemical expression of bone matrix proteins. Our results showed that the use of ozone diluted in water for irrigation caused a delay in early stages of bone repair. This delay was more prominent in the first phase of the bone wound healing.
 
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JulianaNoguti.pdf (1.65 Mbytes)
Publishing Date
2010-07-13
 
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