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Master's Dissertation
DOI
https://doi.org/10.11606/D.17.2020.tde-18122019-152208
Document
Author
Full name
Marília Maria Miguel
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2019
Supervisor
Committee
Arruda, Gustavo Viani (President)
Cavalli, Ricardo de Carvalho
Fernandes, Marco Antonio Rodrigues
Pavoni, Juliana Fernandes
Title in Portuguese
Análise dosimétrica de fatores identificados na braquiterapia 3D e a influência dos mesmos na braquiterapia 2D
Keywords in Portuguese
Braquiterapia de cúpula vaginal
Braquiterapia tridimensional
Tumores ginecológicos
Abstract in Portuguese
O câncer de endométrio e de colo uterino são os tumores ginecológicos mais frequentes em mulheres, tanto em países desenvolvidos quanto em países em desenvolvimento. Globalmente, os tumores ginecológicos representam cerca de 10 a 15% de todas as neoplasias em mulheres. O tratamento primário padrão em estádios precoce inclui histerectomia abdominal total e salpingooforectomia bilateral, com ou sem linfanedectomia. O tratamento adjuvante desses tumores vai depender da presença de fatores clínico-patológicos associados com o risco de recorrência. A braquiterapia faz parte dos protocolos para tratamento de tumores de colo uterino, submetidos à ressecção cirúrgica com os seguintes fatores de risco: linfonodos comprometidos, invasão parametrial e margens comprometidas ou exíguas. A braquiterapia tridimensional diminui a chance de erros geográficos existente nos tratamentos baseados apenas em radiografias e pode, dessa forma, ser mais impactante no controle local e sobrevida de pacientes com tumores ginecológicos. Alguns trabalhos publicados previamente mostram que podem existir interferências dosimétricas de acordo com a variação de alguns fatores como grau de distensão da bexiga, posição do aplicador e o posicionamento da paciente. O objetivo do presente estudo foi avaliar a presença de bolhas entre o aplicador e a parede da vagina e se as mesmas podem causar interferência dosimétrica no tratamento de pacientes submetidas à braquiterapia de cúpula vaginal no Hospital das Clínicas da FMRP-USP.
Title in English
Dosimetric Analysis Of Factors Identified In 3D Brachytherapy And Their Influence In Brachytherapy 2D
Keywords in English
Gynecological tumors
Three dimensional brachytherapy
Vaginal vault brachytherapy
Abstract in English
Endometrial and cervical cancer are the most common gynecological tumors in women, both in developed and developing countries. Overall, gynecological tumors account for about 10 to 15% of all neoplasms in women. Standard primary treatment in early stages includes total abdominal hysterectomy and bilateral salpingo-oophorectomy, with or without lymphadenectomy. The adjuvant treatment of these tumors will depend on the presence of clinical-pathological factors associated with the risk of recurrence. Brachytherapy is part of the protocols for the treatment of uterine cervix tumors submitted to surgical resection with the following risk factors: compromised lymph nodes, parametrial invasion, and compromised or closer margins. Three-dimensional brachytherapy reduces the chance of geographic errors existing in treatments based only on radiographs and may, therefore, be more impacting in the local control and survival of patients with gynecological tumors. Some previously published studies show that there may be dosimetric interference according to the variation of some factors such as degree of bladder distension, position of the applicator and patient positioning. The aim of the present study was to evaluate the presence of air gaps between the applicator and the wall of the vagina and whether they may cause dosimetric interference in the treatment of patients submitted to vaginal vault brachytherapy at University Hospital of the Faculty of Medicine of Ribeirão Preto, University of São Paulo (HCRPUSP).
 
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Publishing Date
2020-01-15
 
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