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Master's Dissertation
DOI
https://doi.org/10.11606/D.17.2006.tde-19122006-145040
Document
Author
Full name
Liana Barbaresco Gomide
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2006
Supervisor
Committee
Reis, Francisco José Cândido dos (President)
Silva, Cristiane Soncino
Terra Filho, João
Title in Portuguese
Repercussões tardias da radioterapia sobre a função pulmonar em pacientes com câncer de mama
Keywords in Portuguese
câncer de mama
dispnéia
função pulmonar
radioterapia
Abstract in Portuguese
A realização de radioterapia adjuvante no tratamento do câncer de mama está comumente associada com complicações pulmonares em curto prazo, mas é questionável se essas alterações podem estar presentes também ao longo do tempo. Este trabalho teve como objetivo avaliar, em mulheres que foram diagnosticadas com câncer de mama, o comportamento da função pulmonar e a presença de dispnéia 18 meses após o término da radioterapia. Para tanto, foi realizado um estudo caso-controle em um grupo de 40 voluntárias não tabagistas e sem doenças cardiorrespiratórias que foram divididas em: irradiadas e controle. No grupo irradiado foram incluídas pacientes que realizaram tratamento conservador para o câncer de mama e que receberam radioterapia adjuvante. No grupo controle participaram voluntárias saudáveis com características físicas, etárias e antropométricas semelhantes ao grupo irradiado. Os parâmetros da função pulmonar como volumes (inclusive residual), capacidade vital forçada, fluxos expiratórios máximos e capacidade de difusão foram obtidos por meio do espirômetro GS Plus da Collins. O sintoma de dispnéia em pacientes irradiadas foi quantificado pela escala de dispnéia do Conselho Britânico de Pesquisas Médicas (MRC). As pacientes que realizaram radioterapia apresentaram valores de CPT, CV, CVF e VEF1 (em percentual do previsto) significativamente menores (p<0,05) que os valores correspondentes obtidos pelas voluntárias controle. Observamos ainda, uma tendência dos parâmetros da função pulmonar diminuírem à medida que o grau de dispnéia aumentava. As pacientes com dispnéia grau 2, apresentaram valores de CV, CVF e VEF1 (em percentual do previsto) significativamente menores que as pacientes que não relataram dispnéia. A detecção de alterações da função pulmonar em fases tardias de pacientes submetidas à radioterapia reforça a necessidade de seguimento longitudinal prolongado pré e pós-procedimento.
Title in English
Long-term pulmonary effects of radiotherapy detected by pulmonary function in breast cancer patients
Keywords in English
breast cancer
dyspnea
pulmonary function
radiotherapy
Abstract in English
Adjuvant radiotherapy for breast cancer is commonly associated with short-term pulmonary complications. Long-term risks of this regimen are, however, still debated. The aim of this study was to evaluate dyspnea and pulmonary function 18 months after radiotherapy in breast cancer patients. The population studied consisted of 40 nonsmoking subjects free of cardiorespiratory disease separate divided in two groups: irradiated and control. In the irradiated group they were included patient that undergone breast-conserving surgery and adjuvant radiotherapy and in the group control healthy subjects with age, height and weight similar to the irradiated group. Pulmonary function parameters as volumes (including residual volume), forced vital capacity, maximum expiratory flow and lung capacity diffusion were obtained through GS Plus Collins spirometer. Dyspnea in the irradiated patients was quantitated by the Medical Research Council (MRC) dyspnea scale. Patients that undergone radiotherapy had values of TLC, VC, FVC and FEV1 (as percent predicted) that were significantly less (p <0,05) than corresponding values for the control subjects. Lung function parameters trended downward as the dyspnea score increased. Patients with level 2 dyspnea, had values of VC, FVC and FEV1 (as percent predicted) that were significantly less than corresponding values for the level 0 dyspnea patients. Changes in pulmonary function detected a long term after radiotherapy in breast cancer patients intensify the achievement follow-up study before and after long term treatment with radiotherapy.
 
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Dissertacao.pdf (585.51 Kbytes)
Publishing Date
2007-01-11
 
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