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Master's Dissertation
DOI
10.11606/D.11.2011.tde-25042011-084213
Document
Author
Full name
Felipe Gabriel Andrino
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Piracicaba, 2010
Supervisor
Committee
Tavares, Flavio Cesar Almeida (President)
Figueira, Antonio Vargas de Oliveira
Lira, Simone Possedente de
Title in Portuguese
Estudo químico de compostos de Solanum Lycopersicum com atividade antifúngica para Moniliophthora perniciosa
Keywords in Portuguese
Alcalóides
Antifúngicos
Basidiomycota
Cacau
Fungos fitopatogênicos
Tomate.
Abstract in Portuguese
O fungo fitopatogênico hemibiotrófico Moniliophthora perniciosa, causador da doença Vassoura-de-Bruxa no cacaueiro (Theobroma cacao), é um dos maiores responsáveis pela contribuição do declínio da produção brasileira de cacau e constitui um problema fitopatológico em todas as regiões cacauicultoras. O gênero Solanum, do qual faz parte o tomate, berinjela, batata entre outros, é bem conhecido na literatura por conterem compostos que exibem atividade biológica tais como antifúngica, antiviral, moluscida, anticancerígena entre outras. O presente trabalho explorou o potencial de extrato bruto de folhas de Solanum lycopersicum como agente inibidor no controle de crescimento e desenvolvimento de três biotipos de M. perniciosa (cacau, solanácea e liana). Através de ensaios biológicos e métodos cromatográficos foi identificado o metabólito secundário -tomatina como responsável pela atividade antifúngica. Este glicoalcalóide, que apresentou potente atividade antifúngica em ensaios in vitro, foi utilizado como agente de controle no desenvolvimento do fungo e manifestação dos sintomas em plantas in vivo, onde foi verificado uma redução significativa no número de plantas com sintomas.
Title in English
Chemical studies of antifungic compounds from Solanum lycopersicum against Moniliophthora perniciosa
Keywords in English
Alpha-tomatine
Antifungal activity
Moniliophthora perniciosa.
Witches broom
Abstract in English
The hemibiotrophic phytopathogenic fungi Moniliophthora perniciosa, agent of witches broom disease of cocoa (Theobroma cacao) is one of the major responsible for the Brazilian cocoa production decay and it is a phytopathological problem in every cocoa yield area. Solanum genera, from each belongs tomatoes, eggplants, potatoes, among others, is well known as producer of biological activity such as antifungal, antiviral, anti mollus, anticancer, etc. This study explored the potential of crude extract leaves from Solanum lycopersicum as an inhibitor agent for the control of growing and development of three M. perniciosa biotypes. By the use of biological assays and chromatography, -tomatine, a secondary metabolite was identified as responsible for antifungal activity. This glycoalcaloid presented great antifungal activity on in vitro assays and it was used on the control and development of witches broom symptoms in vivo, where a significant reduction of symptomatic plants could be observed.
 
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Publishing Date
2011-04-28
 
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