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Master's Dissertation
DOI
10.11606/D.100.2019.tde-17122018-134118
Document
Author
Full name
Thiago Reinaldos Silva
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2018
Supervisor
Committee
Campana, Patricia Targon (President)
Baruque Ramos, Júlia
Cardoso, Alexandre Bruni
Marletta, Alexandre
Title in Portuguese
Produção de scaffolds poliméricos por Electrospinning a partir do polímero PLGA com adição de moléculas de interesse para o aprimoramento de tecidos biomiméticos
Keywords in Portuguese
Scaffolds poliméricos
Biomateriais
Electrospinning
PLGA
Abstract in Portuguese
O desenvolvimento de scaffolds para a aplicação em biomateriais, seja na produção de tecidos biomiméticos ou mesmo em sistemas para liberação de drogas, tem sido fundamental tanto para o entendimento dos mecanismos de crescimento de tecidos biológicos e seu funcionamento, quanto para o desenvolvimento de biomateriais que possam ser incorporados aos tecidos naturais para seu reparo e para a efetiva aplicação de agentes terapêuticos. Dentre as várias técnicas para a produção destes scaffolds, a técnica de Electrospinning (ES) foi utilizada neste trabalho para a confecção de scaffolds poliméricos com a incorporação moléculas de interesse biotecnológico. Foram produzidos scaffolds e scaffolds compósitos pela adição de nanopartículas de óxido de cério, nanoargila haloisita e protoporfirina IX complexada à nanoargila haloisita, os quais foram estudados quanto à sua morfologia e propriedades tênseis, além de terem sidos testados quanto a sua viabilidade como sistemas biomiméticos de tecidos. Os scaffolds compósitos mostraram um ganho em ordenamento e homogeneidade, e os scaffolds compósitos contendo óxido de cério mostraram um leve aumento em sua capacidade elástica, além de terem sido viáveis para o crescimento de células HCat
Title in English
Electrospun polymeric scaffolds of PLGA with encapsulation of molecules of biotechnological interest for biomimetic tissue enhancement
Keywords in English
Biomaterials
Electrospinning
PLGA
Polymeric Scaffolds
Abstract in English
The development of scaffolds for biomaterials applications, in biomimetic tissues production and drug-delivery systems, have been a fundamental tool for the understanding of biological tissues growing and repair mechanisms and for the development of biomaterials that can be incorporated to the natural tissues for both repair and effective application of therapeutic agents. Amongst the several techniques for scaffolds production, the Electrospinning (ES) methodology was applied in this work for developing polymeric scaffolds with the encapsulation of molecules of biotechnological interest. Scaffolds and blend scaffolds by cerium oxide nanoparticles and haloisite nanoclay addiction were produced and studied regarding its morphology, tensile properties and cell viability as biomimetic tissues. The blend scaffolds shoed an enhancement in order and homogeneity, and those within cerium oxide showed also an increase in elastic capacity and viable physical base for HCat cells
 
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Publishing Date
2019-03-15
 
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