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Master's Dissertation
DOI
https://doi.org/10.11606/D.10.2010.tde-27012012-101434
Document
Author
Full name
Eduardo Perlmann
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Barros, Paulo Sergio de Moraes (President)
Martins, Maria Cristina
Safatle, Angélica de Mendonça Vaz
Title in Portuguese
Estudo morfológico das neoplasias melanocíticas uveais em cães
Keywords in Portuguese
Cães
Melanocitoma
Melanoma
Uvea
Abstract in Portuguese
Os tumores de origem melanocítica representam as mais frequentes neoplasias intra-oculares diagnosticadas nos cães. O presente trabalho teve por objetivo realizar estudo retrospectivo das neoplasias melanocíticas da úvea do cão analisando suas características morfológicas e epidemiológicas. Foi estudado um total de 29 casos; destas, 51,7 % foram diagnosticadas como melanocitoma, enquanto que 48,3 % como melanoma. As raças mais acometidas foram SRD (sem raça definida), Cocker Spaniel Inglês e Labrador Retriver, porém não houve predominância racial significativa. A faixa etária foi de 6 a 15 anos, com média de 10,3 anos. Os tumores acometeram igualmente machos e fêmeas. A úvea anterior foi a localização mais comum, representando 96,5 % de todos os tumores, enquanto a úvea posterior representou 3,5 %, sendo o último, um melanoma. Em 5 casos, o tumor ocupava todo espaço intra-ocular, sendo todos melanomas. Os melanocitomas apresentaram predominância de células grandes, redondas ou poliédricas, densamente pigmentadas e núcleo pequeno. Os melanomas apresentaram 2 padrões celulares distintos. Dos 14 melanomas, 8 (57,2 %) eram compostos por células epitelióides, 2 (14,3 %) por células fusiformes, e 4 (28,5%) apresentaram padrão misto. Em 7 melanomas observou-se áreas de melanocitoma, sugerindo transformação maligna.
Title in English
Morphologic study of the uveal melanocytic neoplasias in dogs
Keywords in English
Dogs
Melanocitoma
Melanoma
Uvea
Abstract in English
Melanocytic tumors are the most common intraocular neoplasia in dogs. The aim of the present work was to perform a retrospective study of the canine uveal melanocytic neoplasias analyzing the morphologic and epidemiologic features. It was 29 cases in total; 51,7 % was diagnosed as melanocitoma, while 48,3 % was diagnosed as melanoma. The most common breed was mixed breed dogs, English Cocker Spaniel and Labrador, but there was no significant racial predominance. The age range was 6 to 15 years old, with mean of 10,3 years old. The tumors affected equally males and females. The anterior uvea was the most common site, representing 95,5 % of all tumors and the posterior uvea represented 3,5 %, the latter, was a melanoma. In five cases (17,2%), the tumor occupied the entire intraocular space, all of them melanomas. The melanocitomas presented predominance of round or poliedric, plump cells, densely pigmented with small nucleus. The melanomas presented two distinct patterns. Of the 14 melanomas, eight (57,2 %) was composed of epithelioid cells, two (14,3 %) of spindle cells, and four (28,5 %) presented mixed pattern. There were 7 melanomas that presented melanocitoma areas, suggesting malignant transformation.
 
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EDUARDO_PERLMANN.pdf (1.73 Mbytes)
Publishing Date
2013-04-19
 
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