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Mémoire de Maîtrise
DOI
https://doi.org/10.11606/D.10.2010.tde-28012011-152926
Document
Auteur
Nom complet
Wilsilene Aparecida Silva Coelho
Adresse Mail
Unité de l'USP
Domain de Connaissance
Date de Soutenance
Editeur
São Paulo, 2010
Directeur
Jury
Soto, Francisco Rafael Martins (Président)
Genovez, Margareth Elide
Vasconcellos, Silvio Arruda
Titre en portugais
Potência de bacterinas anti-leptospirose canina comercializadas no Brasil: desafio efetuado  com estirpes autóctones dos sorovares Canicola e Copenhageni
Mots-clés en portugais
Cães
Hamsters
Leptospirose animal
Potência
Vacina
Resumé en portugais
Foi efetuada a avaliação comparativa da potência de vacinas anti-leptospirose canina comercializadas no Brasil, empregando no desafio estirpes de leptospiras dos sorovares Canicola e Copenhageni autoctones isoladas no Brasil. Foram comparadas nove bacterinas comerciais polivalentes produzidas para uso em cães, identificadas pelas letras A, B, C, D, E, F, G, H e I. O desafio foi efetuado com as estirpes L1-130 e LO4, respectivamente dos sorovares Copenhageni e Canicola tipificadas pela prova de anticorpos monoclonais. O protocolo adotado seguiu as normas técnicas americanas, 9 CFR 113.103 Leptospirose Canicola - 2006 . A dose infectante do sorovar Copenhageni empregada no desafio (5,4) foi inferior ao limite inferior estabelecido pela norma técnica (10) e a do sorovar Canicola foi de 10.000. Os animais foram observados por 21 dias consecutivos, contabilizando-se os que morreram por leptospirose. Ao final deste período, os sobreviventes foram submetidos à eutanásia por inalação de gás carbônico (câmara de CO2), e necropsiados para colheita dos rins e realização de cultivos destinados ao controle de infecção renal por leptospiras. Das nove vacinas avaliadas, sete foram reprovadas para os dois sorovares testados e duas foram aprovadas contra a doença clinica e infecção renal para o sorovar Canicola LO4, porém apenas contra a doença clínica para o sorovar Copenhageni L1-130. Os laboratórios fabricantes de bacterinas anti-leptospirose canina que estão sendo comercializadas no Brasil, necessitam rever a qualidade dos seus produtos no relativo a proteção contra a doença e infecção pelos sorovares Canicola e Copenhageni.
Titre en anglais
Potency of canine anti-leptospirosis bacterins marketed in Brazil: challenge effectuated with indigenous strains of the serovars Canicola and Copenhageni.
Mots-clés en anglais
Animal leptospirosis
Dogs
Hamsters
Potency
Vaccines
Resumé en anglais
A comparative evaluation of the potency of canine anti-leptospirosis bacterins marketed in Brazil was conducted using as the challenge strains the indigenous leptospires, serovars Canicola and Copenhageni, isolated in Brazil. There were compared nine commercial polyvalent bacterial vaccines produced for use in dogs, identified by the letters A, B, C, D, E, F, G, H and I. The challenge was performed with L1-130 and LO4 strains, respectively, of the serovars Copenhageni and Canicola, which have been typified by the monoclonal antibodies (MABs). The adopted protocol followed the American standard techniques, 9 CFR 113.103 Leptospirosis Canicola 2006. The infectious dose of the serovar Copenhageni used in the challenge (5.4) was inferior to the lower limit established by the technical standard (10) and that of the serovar Canicola was of 10,000. The animals (hamsters) were observed for 21 consecutive days, registering those died of leptospirosis. At the end of the observation period, the survivors were subdued to the euthanasia by inhalation of carbon gas (CO2 chamber), and necropsied, taking the kidneys for bacterial culturing for the evaluation of renal infection by leptospires. Among nine evaluated vaccines, seven failed for the two serovars tested and two were approved against the clinical disease and renal infection by the serovar Canicola LO4, however serovar Copenhageni L1-130 was effective only against manifestation of the clinical disease. The manufacturers of the canine anti-leptospirosis bacterial vaccines which are being marketed in Brazil need to revise the quality of their products in respect to the protection conferred against the disease and against the infection by the serovars Canicola and Copenhageni.
 
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Date de Publication
2011-02-15
 
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